Stem cell-based multi-tissue platforms to model human autoimmune diabetes

Consortia: CHIB, CMAI

Leavens KF, Alvarez-Dominguez JR, Vo LT, Russ HA, Parent AV.
Mol Metab. 2022 Oct 6:101610. doi: 10.1016/j.molmet.2022.101610. Online ahead of print. PMID:36209784

All Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells DNA methylation-based assessment of cell composition in human pancreas and islets A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis Local dialogues between the endocrine and exocrine cells in the pancreas KD025 is a casein kinase 2 inhibitor that protects against glucolipotoxicity in beta cells SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition NADPH Oxidase 2-Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function Protection of β cells against pro-inflammatory cytokine stress by the GDF15-ERBB2 signaling How to Test Human CAR T Cells in Solid Tumors, the Next Frontier of CAR T Cell Therapy Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes RFX6 maintains gene expression and function of adult human islet α cells Simplified homology-assisted CRISPR for gene editing in Drosophila Genetic risk converges on regulatory networks mediating early type 2 diabetes Beta-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network A proteomic meta-analysis refinement of plasma extracellular vesicles Modulation of insulin secretion by RBFOX2-mediated alternative splicing K(ATP) channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells Checkpoint kinase 2 controls insulin secretion and glucose homeostasis HNF1α maintains pancreatic α and β cell functions in primary human islets Stress-induced β cell early senescence confers protection against type 1 diabetes Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals A bright future for glucagon and alpha cell biology Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes Deconstructing the integrated oscillator model for pancreatic β-cells The leptin receptor has no role in delta-cell control of beta-cell function in the mouse Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses The beta cell-immune cell interface in type 1 diabetes (T1D) Complementary Approaches to Interrogate Mitophagy Flux in Pancreatic β-Cells Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
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