Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Consortia: CBDS, HPAC

Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium, Faryabi RB, Naji A, Kaestner KH, Vahedi G.
Nat Metab. 2022 Feb;4(2):284-299. doi: 10.1038/s42255-022-00531-x. Epub 2022 Feb 28. PMID:35228745

All Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells Mouse models and human islet transplantation sites for intravital imaging Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells Yo-Yo Dieting: Mixed Messages for β-Cell Plasticity Stem cell-based multi-tissue platforms to model human autoimmune diabetes Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Fluorescence imaging of beta cell primary cilia Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes Identification of T cell antigens in the 21st century, as difficult as ever Editorial: alternative antigen processing and presentation in immune disorders Islet primary cilia motility controls insulin secretion d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes 3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15 Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor Precision medicine in type 1 diabetes Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia Every islet matters: improving the impact of human islet research Adaptation to chronic ER stress enforces pancreatic β-cell plasticity Predicting Misdiagnosed Adult-onset Type 1 Diabetes Using Machine Learning EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? The Yin and Yang of Modulating β-Cell DNA Damage Response and Functional Mass Cilia Action in Islets: Lessons From Mouse Models Integrating Additive Manufacturing Techniques to Improve Cell-Based Implants for the Treatment of Type 1 Diabetes Characterizing cis-regulatory elements using single-cell epigenomics Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors Increasing insulin measurement throughput by fluorescence anisotropy imaging immunoassays α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy Polycomb Repressive Complexes: Shaping Pancreatic Beta-Cell Destiny in Development and Metabolic Disease The Foundation for Engineering a Pancreatic Islet Niche
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