Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program

Consortia: CBDS, HPAC

Patil AR, Schug J, Naji A, Kaestner KH, Faryabi RB, Vahedi G.
Nat Metab. 2023 May;5(5):713-715. doi: 10.1038/s42255-023-00806-x. PMID:37188822

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? 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