RIPK3-mediated inflammation is a conserved β cell response to ER stress

Consortia: CBDS, CTAR, HPAC

Yang B, Maddison LA, Zaborska KE, Dai C, Yin L, Tang Z, Zang L, Jacobson DA, Powers AC, Chen W.
Sci Adv. 2020 Dec 18;6(51):eabd7272. doi: 10.1126/sciadv.abd7272. Print 2020 Dec. PMID:33355143

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and critical illness Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity A DNA methylation atlas of normal human cell types Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes 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stress in type 1 diabetes Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes Islet cilia and glucose homeostasis Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation Microwell culture platform maintains viability and mass of human pancreatic islets The dichotomous outcomes of TNFα signaling in CD4(+) T cells Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning Generation of non-human primate CAR Tregs using artificial antigen-presenting cells, simian tropic lentiviral vectors, and antigen-specific restimulation Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis Geometric engineering of organoid culture for enhanced organogenesis in a dish Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells Mouse models and human islet transplantation sites for intravital imaging Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells Yo-Yo Dieting: Mixed Messages for β-Cell Plasticity Stem cell-based multi-tissue platforms to model human autoimmune diabetes Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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