Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) α-cells

Consortia: CBDS, CTAR

Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL.
Nat Cell Biol. 2018 Nov;20(11):1267-1277. doi: 10.1038/s41556-018-0216-y. PMID:30361701

All Transcription factors combine to paint the methylation landscape Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry Microvessels enhance vascularization and function of transplanted insulin-producing cells Adult-Onset Type 1 Diabetes: Current Understanding and Challenges The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas Human islet T cells are highly reactive to preproinsulin in type 1 diabetes Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance Probing β-Cell Biology in Space and Time ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 New-onset IgG autoantibodies in hospitalized patients with COVID-19 A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype Combinatorial transcription factor profiles predict mature and functional human islet α and β cells From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) Review Series The pancreatic β cell response to secretory demands and adaption to stress A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass Beta Cell Autophagy in the Pathogenesis of Type 1 Diabetes Insulin immunotherapy for pretype 1 diabetes Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4(+) T Cell Activation Generation of functional human thymic cells from induced pluripotent stem cells Strategies for durable β cell replacement in type 1 diabetes 100 years of insulin: celebrating the past, present and future of diabetes therapy A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP(C), in type 1 diabetes Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs Imaging alloreactive T cells provides early warning of organ transplant rejection Genetic engineering of T cells for immunotherapy From type 1 diabetes biology to therapy: The Human Islet Research Network Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines New Aspects of Diabetes Research and Therapeutic Development Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Designing biomaterials for the modulation of allogeneic and autoimmune responses to cellular implants in Type 1 Diabetes A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data
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