NADPH Oxidase 2-Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function

Consortia: CMAI

Chen J, Liu C, Chernatynskaya AV, Newby B, Brusko TM, Xu Y, Barra JM, Morgan N, Santarlas C, Reeves WH, Tse HM, Leiding JW, Mathews CE.
J Immunol. 2023 Dec 11:ji2200691. doi: 10.4049/jimmunol.2200691. PMID:38079221

All Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells CNTools: A computational toolbox for cellular neighborhood analysis from multiplexed images Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry 12-Lipoxygenase inhibition suppresses islet immune and inflammatory responses and delays autoimmune diabetes in human gene replacement mice No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data Diabetes mellitus-Progress and opportunities in the evolving epidemic Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h Identification of unique cell type responses in pancreatic islets to stress The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes HumanIslets: An integrated platform for human islet data access and analysis A metabolic redox relay supports ER proinsulin export in pancreatic islet β-cells Untangling the genetics of beta cell dysfunction and death in type 1 diabetes Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival? Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Unfolding emergency calls stress granules to the ER Immuno-Scanning Electron Microscopy of Islet Primary Cilia Human insulin as both antigen and protector in type 1 diabetes A Golden Hour and Golden Opportunity for β-Cell Preservation The integrated stress response in pancreatic development, tissue homeostasis, and cancer Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets Data-driven selection of analysis decisions in single-cell RNA-seq trajectory inference AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation De novo identification of CD4(+) T cell epitopes Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production in vitro and in vivo High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective
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