Modeling human T1D-associated autoimmune processes

Consortia: CMAI, Opportunity Pool Projects

Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ.
Mol Metab. 2021 Dec 10;56:101417. doi: 10.1016/j.molmet.2021.101417.  PMID:34902607

All The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes Modeling human T1D-associated autoimmune processes Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles’ Heel? Transcription factors combine to paint the methylation landscape Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry Microvessels enhance vascularization and function of transplanted insulin-producing cells Adult-Onset Type 1 Diabetes: Current Understanding and Challenges Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas Human islet T cells are highly reactive to preproinsulin in type 1 diabetes Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance Probing β-Cell Biology in Space and Time ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 New-onset IgG autoantibodies in hospitalized patients with COVID-19 A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype Combinatorial transcription factor profiles predict mature and functional human islet α and β cells From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) Review Series A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus The pancreatic β cell response to secretory demands and adaption to stress Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass Beta Cell Autophagy in the Pathogenesis of Type 1 Diabetes Insulin immunotherapy for pretype 1 diabetes Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4(+) T Cell Activation Generation of functional human thymic cells from induced pluripotent stem cells Strategies for durable β cell replacement in type 1 diabetes 100 years of insulin: celebrating the past, present and future of diabetes therapy A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP(C), in type 1 diabetes Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs
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