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m 6 A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation
Consortia:
CBDS
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K(ATP) channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
HNF1α maintains pancreatic α and β cell functions in primary human islets
Stress-induced β cell early senescence confers protection against type 1 diabetes
Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals
A bright future for glucagon and alpha cell biology
Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity
Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes
Deconstructing the integrated oscillator model for pancreatic β-cells
The leptin receptor has no role in delta-cell control of beta-cell function in the mouse
Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm
Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells
Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors
Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response
Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
The beta cell-immune cell interface in type 1 diabetes (T1D)
Complementary Approaches to Interrogate Mitophagy Flux in Pancreatic β-Cells
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies
Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging
Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network
Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2
Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits
Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation
Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging
Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
A Chicken Tapasin ortholog can chaperone empty HLA-B∗37:01 molecules independent of other peptide-loading components
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
m 6 A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation
Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
Protein disorder in the regulatory control of mitophagy
Not the second fiddle: α cell development, identity and function in health and diabetes
Human immune phenotyping reveals accelerated aging in type 1 diabetes
Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
Cancer-associated fibroblast classification in single-cell and spatial proteomics data
Inferring regulators of cell identity in the human adult pancreas
Generation of the NeoThy mouse model for human immune system studies
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
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hirnec@coh.org