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Islet cilia and glucose homeostasis
Consortia:
HPAC
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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Redox Regulation of m (6) A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
Scanning electron microscopy of human islet cilia
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes
Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity
An integrated map of cell type-specific gene expression in pancreatic islets
Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes
DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity
A DNA methylation atlas of normal human cell types
Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program
Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes
Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets
Synthetic cytokine circuits that drive T cells into immune-excluded tumors
The emerging landscape of spatial profiling technologies
Protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas for mass cytometric analyses
Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes
The emerging role of regulatory cell-based therapy in autoimmune disease
Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I
Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation
Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes
Islet cilia and glucose homeostasis
Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
Microwell culture platform maintains viability and mass of human pancreatic islets
The dichotomous outcomes of TNFα signaling in CD4(+) T cells
Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines
Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies
Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning
Generation of non-human primate CAR Tregs using artificial antigen-presenting cells, simian tropic lentiviral vectors, and antigen-specific restimulation
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
Geometric engineering of organoid culture for enhanced organogenesis in a dish
Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity
Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Mouse models and human islet transplantation sites for intravital imaging
Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells
Yo-Yo Dieting: Mixed Messages for β-Cell Plasticity
Stem cell-based multi-tissue platforms to model human autoimmune diabetes
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
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