Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

Consortia: CBDS, CHIB

Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA.
Cell Rep. 2020 May 12;31(6):107623. doi: 10.1016/j.celrep.2020.107623. PMID:32402282

All Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Target Discovery to Diabetes Therapy-TXNIP From Bench to Bedside With NIDDK IFN-α Induces Heterogenous ROS Production in Human β-Cells Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes 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dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides
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