Generation of the NeoThy mouse model for human immune system studies

Consortia: CMAI

Del Rio NM, Huang L, Murphy L, Babu JS, Daffada CM, Haynes WJ, Keck JG, Brehm MA, Shultz LD, Brown ME.
Lab Anim (NY). 2023 Jul;52(7):149-168. doi: 10.1038/s41684-023-01196-z. Epub 2023 Jun 29. PMID:37386161

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Unfolding emergency calls stress granules to the ER Immuno-Scanning Electron Microscopy of Islet Primary Cilia Human insulin as both antigen and protector in type 1 diabetes A Golden Hour and Golden Opportunity for β-Cell Preservation The integrated stress response in pancreatic development, tissue homeostasis, and cancer Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets Data-driven selection of analysis decisions in single-cell RNA-seq trajectory inference AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation De novo identification of CD4(+) T cell epitopes Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes
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