Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15

Consortia: CMAI

Aryee KE, Burzenski LM, Yao LC, Keck JG, Greiner DL, Shultz LD, Brehm MA.
FASEB J. 2022 Sep;36(9):e22476. doi: 10.1096/fj.202200045R. PMID:35959876

All Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity A DNA methylation atlas of normal human cell types Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets The emerging landscape of spatial profiling technologies Synthetic cytokine circuits that drive T cells into immune-excluded tumors Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes The emerging role of regulatory cell-based therapy in autoimmune disease Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes Islet cilia and glucose homeostasis Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies Geometric engineering of organoid culture for enhanced organogenesis in a dish Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells Mouse models and human islet transplantation sites for intravital imaging Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells Yo-Yo Dieting: Mixed Messages for β-Cell Plasticity Stem cell-based multi-tissue platforms to model human autoimmune diabetes Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Fluorescence imaging of beta cell primary cilia Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes Identification of T cell antigens in the 21st century, as difficult as ever Editorial: alternative antigen processing and presentation in immune disorders Effects of Pro-Inflammatory Cytokines on the Pancreatic Islet Transcriptome: A View at Both Temporal and Single-Cell Resolution Islet primary cilia motility controls insulin secretion d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice 3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15 Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor Precision medicine in type 1 diabetes Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia Every islet matters: improving the impact of human islet research Adaptation to chronic ER stress enforces pancreatic β-cell plasticity Predicting Misdiagnosed Adult-onset Type 1 Diabetes Using Machine Learning EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? The Yin and Yang of Modulating β-Cell DNA Damage Response and Functional Mass
Follow
×

Follow

us on our social networks.