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Complementary Approaches to Interrogate Mitophagy Flux in Pancreatic β-Cells
Consortia:
CBDS
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Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells
CNTools: A computational toolbox for cellular neighborhood analysis from multiplexed images
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners
Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements
Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry
12-Lipoxygenase inhibition suppresses islet immune and inflammatory responses and delays autoimmune diabetes in human gene replacement mice
No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data
Diabetes mellitus-Progress and opportunities in the evolving epidemic
Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells
CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Identification of unique cell type responses in pancreatic islets to stress
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes
HumanIslets: An integrated platform for human islet data access and analysis
A metabolic redox relay supports ER proinsulin export in pancreatic islet β-cells
Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival?
Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice
Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels
Roadblocks confronting widespread dissemination and deployment of Organs on Chips
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
Unfolding emergency calls stress granules to the ER
Immuno-Scanning Electron Microscopy of Islet Primary Cilia
Human insulin as both antigen and protector in type 1 diabetes
A Golden Hour and Golden Opportunity for β-Cell Preservation
The integrated stress response in pancreatic development, tissue homeostasis, and cancer
Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets
Data-driven selection of analysis decisions in single-cell RNA-seq trajectory inference
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets
Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation
De novo identification of CD4(+) T cell epitopes
Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes
IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production in vitro and in vivo
High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation
miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis
A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling
Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis
Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery
Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective
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