Cell maturation: Hallmarks, triggers, and manipulation

Consortia: CHIB, Opportunity Pool Projects

Alvarez-Dominguez JR, Melton DA.
Cell. 2021 Dec 30:S0092-8674(21)01450-1. doi: 10.1016/j.cell.2021.12.012. PMID:34995481

All Interpreting non-coding disease-associated human variants using single-cell epigenomics Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation Rediscovering Primary Cilia in Pancreatic Islets The human α cell in health and disease Stomach-derived human insulin-secreting organoids restore glucose homeostasis Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration Ca(2+) Release or Ca(2+) Entry, that is the Question: What Governs Ca(2+) Oscillations in Pancreatic Beta Cells? Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes? Peeling the onion: another layer in the regulation of insulin secretion Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells Generation of functional thymic organoids from human pluripotent stem cells A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis Reference compounds for characterizing cellular injury in high-content cellular morphology assays Redox Regulation of m (6) A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes Scanning electron microscopy of human islet cilia Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity Metabolic Messengers: glucagon An integrated map of cell type-specific gene expression in pancreatic islets Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness A genetic strategy to measure insulin signaling regulation and physiology in Drosophila Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity A DNA methylation atlas of normal human cell types Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets Synthetic cytokine circuits that drive T cells into immune-excluded tumors The emerging landscape of spatial profiling technologies Protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas for mass cytometric analyses Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes The emerging role of regulatory cell-based therapy in autoimmune disease Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
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