Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling

Consortia: HPAC

Trück J, Eugster A, Barennes P, Tipton CM, Luning Prak ET, Bagnara D, Soto C, Sherkow JS, Payne AS, Lefranc MP, Farmer A; AIRR Community, Bostick M, Mariotti-Ferrandiz E. Elife. 2021 May 26;10:e66274. doi: 10.7554/eLife.66274. PMID: 34037521

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antigens Exendin-4 enhances insulin-positive phenotype of human pluripotent stem cell-derived β cells during transplantation Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety Improved conditioning for hematopoietic chimerism induces islet tolerance to cure diabetes OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy Streamlining Multiplexed Tissue Image Analysis with PIPΣX: An Integrated Automated Pipeline for Image Processing and EXploration for Diverse Tissue Types Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation Ultrasmall chemogenetic tags with group-transfer ligands Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123 Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy Isolation of live human δ cells for genetic and functional analysis Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells Comprehensive molecular impact mapping of common and rare variants at GWAS loci 3D imaging of human pancreas suggests islet sizeand endocrine composition influence their loss intype 1 diabetes RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells Solution mapping of MHC-I:TCR interactions using a minimalistic protein system T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Insulin post-transcriptional regulation via PARP12-mediated ADP- ribosylation Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids
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