An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy

Consortia: CBDS

Gingerich MA, Liu X, Chai B, Pearson GL, Vincent MP, Stromer T, Zhu J, Sidarala V, Renberg A, Sahu D, Klionsky DJ, Schnell S, Soleimanpour SA.
Autophagy. 2022 May 23. doi: 10.1080/15548627.2022.2080383. Online ahead of print. PMID:35604110

All IFN-α Induces Heterogenous ROS Production in Human β-Cells Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis Expanding the engineered Treg multiverse TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy A Recombinase-Mediated Cassette Exchange Platform for a Triple Independent Inducible Expression System for Human Pluripotent Stem Cells Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Identification of a vimentin-expressing α-cell phenotype in CF and normal pancreas Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes Generation of Human Chimeric Antigen Receptor Regulatory T Cells NKX2.2 and KLF4 cooperate to regulate α-cell identity Divergent roles of m(6)A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading BETA CELL DYSFUNCTION OCCURS INDEPENDENTLY OF INSULITIS IN TYPE 1 DIABETES PATHOGENESIS TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model SARS-CoV-2 Spike S1 subunit triggers pericyte and microvascular dysfunction in human pancreatic islets T Cell Development and Responses in Human Immune System Mice LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype HistoPlexer: Histopathology-based Protein Multiplex Generation using Deep Learning Targeting peptide antigens using a multiallelic MHC I-binding system Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells β-Cell gene expression stress signatures in types 1 and 2 diabetes 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver HumanIslets.com: Improving accessibility, integration, and usability of human research islet data Cryopreservation of Stem Cell-Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset Role of Sec61α2 translocon in insulin biosynthesis m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
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