An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts

Consortia: CBDS

Yang L, Han Y, Jaffré F, Nilsson-Payant BE, Bram Y, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Xiang J, Ho DD, tenOever BR, Schwartz RE, Evans T, Chen Z, Chen S. Circ Res. 2021 Apr 15. doi: 10.1161/CIRCRESAHA.121.319060. PMID: 33853355

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beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123 Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy Isolation of live human δ cells for genetic and functional analysis Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells Comprehensive molecular impact mapping of common and rare variants at GWAS loci 3D imaging of human pancreas suggests islet sizeand endocrine composition influence their loss intype 1 diabetes RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells Solution mapping of MHC-I:TCR interactions using a minimalistic protein system T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Insulin post-transcriptional regulation via PARP12-mediated ADP- ribosylation Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids
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