A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion

Consortia: CMAI

Yang K, O’Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM.
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2101258118. doi: 10.1073/pnas.2101258118. PMID:34504013

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oscillator model for pancreatic β-cells The leptin receptor has no role in delta-cell control of beta-cell function in the mouse Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response
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