Bio

Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.

Bio

Rafael Arrojo e Drigo is a Gateway Award Recipient and co-Investigator on a HPAC Grant. He is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine. His research focuses on understanding the mechanisms regulating post-mitotic cell homeostasis and longevity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-rafael-arrojo-e-drigo?hilite=%27rafael%27

Projects

• Mapping the Association of Beta Cell Longevity and Senescence in T1D
• Linking Islet Cell Function and Identity from in vitro to in situ

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rafael+Arrojo+e+Drigo

Bio

Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Bio

Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rcreusot?hilite=Remi+Creusot

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Bio

George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gdaley?hilite=George+Daley

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=George+Daley

Bio

Peter Gottlieb is a Professor at the University of Colorado Anschutz Medical Campus. His laboratory projects are designed to advance basic knowledge of the immune response to autoantigens in type 1 diabetes with the goal of designing immunotherapies for prediabetes and new onset type 1 subjects.

Projects

• Analysis of Human Autoreactive T Cell Receptors in vivo
• Role of Granular Acidification in the Pathogenesis of Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Peter+Gottlieb

Bio

Dale Greiner is the Chair in Biomedical Research and Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. His research focuses on the development and use of a unique mouse model, engrafted with functional human cells and tissues. His work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes, cancer, infectious disease, regenerative medicine and autoimmunity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_dgreiner?hilite=Dale+Greiner

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dale+Greiner

Bio

Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=David+Harlan

Bio

Maki Nakayama is an Associate Professor in the School of Medicine at the University of Colorado Anschutz Medical Campus. Her research strives to understand the mechanism of initiation of anti-beta cell autoimmunity. She focuses on the tri-molecular complex consisting of antigen, major histocompatibility complex (MHC), and T cell receptor (TCR) that could be a key component for the development of T1D.

Projects

• Analysis of Human Autoreactive T Cell Receptors in vivo
• Role of Granular Acidification in the Pathogenesis of Type 1 Diabetes
• Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Maki+Nakayama

Bio

Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.

Projects

• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• iSTAR Tregs

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Audrey+Parent

Bio

Leonard Shultz is a Professor at the Jackson Laboratory. His research leverages immunodeficient mouse models for translational studies on human hematopoiesis, immunity, autoimmunity, infectious diseases, diabetes, regenerative medicine and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lshultz?hilite=Leonard+Shultz

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leonard+Shultz

Bio

Megan Sykes is a Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director, Columbia Center for Translational Immunology. Her research focus is on hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes. The Sykes lab has pioneered minimal conditioning approaches for using HCT to achieve allograft tolerance.

Projects

• Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Megan+Sykes

Bio

Qizhi Tang is a Professor of Transplant Surgery and the Director, Transplantation Research Laboratory at the University of California, San Francisco. Her research focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection.

Projects

• Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs
• Therapeutic Targeting of the Human Islet Environment

Investigator Contributed Resources:

https://www.linkedin.com/in/qizhi-tang-28a0a412/

Bio

Matthias von Herrath is a Professor at the La Jolla Institute for Allergy and Immunology and Vice President, Novo Nordisk Research. His expertise and main strength is working at the interface of experimental research to interpret and refine early phase I/II clinical trials in order to optimize strategies for phase 3 trials and drug approval.