Bio

Kristin Abraham is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are the role of the immune response in metabolic dysfunction and type 2 Diabetes, and projects that develop and validate the utility of new animal models for basic and preclinical research in diabetes, endocrinology and metabolic diseases.

Bio

Mark Anderson is an Endocrinologist and Professor of Medicine at the University of California, San Diego. His research focuses on examining the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_manderson?hilite=Mark+S.+Anderson

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mark+S.+Anderson

Bio

Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.

Bio

Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Bio

Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rcreusot?hilite=Remi+Creusot

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Bio

George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gdaley?hilite=George+Daley

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=George+Daley

Bio

Leonardo Ferreira is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. His research focuses on phenomenon of immune tolerance, his long term goal is to control how the immune system defines self and non-self. Such knowledge will allow the design and development of powerful new engineered immune cell therapies to fight autoimmune disease, cancer, and aging.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-leonardo-m-r-ferreira

Projects

• Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells

Bio

Robin Goland is a Professor of Medicine and Pediatrics at Columbia University, and directs the patient care and clinical research programs at the Berrie Diabetes Center.

Projects

• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Robin+Goland

Bio

Dale Greiner is the Chair in Biomedical Research and Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. His research focuses on the development and use of a unique mouse model, engrafted with functional human cells and tissues. His work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes, cancer, infectious disease, regenerative medicine and autoimmunity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_dgreiner?hilite=Dale+Greiner

Projects

• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dale+Greiner

Bio

Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=David+Harlan

Bio

Sally Kent is an Associate Professor in the Department of Medicine at the UMass Chan Medical School. My research focuses on the area of the autoimmune response in human T1D: in particular, T cell responses in the periphery, in spleen and pancreatic lymph nodes and in islet-infiltrating lymphocytes from subjects with T1D, at-risk for T1D and from controls.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_skent?hilite=Sally+Kent

Projects

• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
• Humanized Mouse Avatars for T1D
• Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Sally+Kent

Bio

Bayou Liu is a Gateway Award Recipient and an Assistant Professor in the Department of Pathology at the University of Utah. His research focuses on autoimmune diseases (e.g., type I diabetes) via understanding self-antigen recognition by the immune system.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-baoyu-liu

Projects

• On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Baoyu+Liu

Bio

Rene Maehr is an Associate Professor in Molecular Medicine at UMass Chan Medical School. His research focuses on investigating how normal differentiation of the thymic epithelial cell lineage is regulated, and recapitulating that process with pluripotent stem cells.

Projects

• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rene+Maehr

Bio

Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.

Lab:

https://hirnetwork.org/about/participants#short-profile-mark-s-anderson-md-phd

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Audrey+Parent

Bio

Leonard Shultz is a Professor at the Jackson Laboratory. His research leverages immunodeficient mouse models for translational studies on human hematopoiesis, immunity, autoimmunity, infectious diseases, diabetes, regenerative medicine and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lshultz?hilite=Leonard+Shultz

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leonard+Shultz

Bio

Lawrence Stern is a Professor of Biochemistry and Molecular Biology at the UMass Chan Medical School. His research interest is in the biochemical processes that underlie cellular recognition and signaling. His lab concentrates on the immune system, because of its intrinsic importance to human health and disease, and because of its treasure of biochemical mechanisms by which cells communicate with their environment and with each other.

Projects

• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function

Bio

Megan Sykes is a Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director, Columbia Center for Translational Immunology. Her research focus is on hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes. The Sykes lab has pioneered minimal conditioning approaches for using HCT to achieve allograft tolerance.

Projects

• Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Megan+Sykes

Bio

Qizhi Tang is a Professor of Transplant Surgery and the Director, Transplantation Research Laboratory at the University of California, San Francisco. Her research focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection.

Projects

• Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs
• Therapeutic Targeting of the Human Islet Environment

Investigator Contributed Resources:

https://www.linkedin.com/in/qizhi-tang-28a0a412/