Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Bio

Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.

Bio

Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Bio

Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rcreusot?hilite=Remi+Creusot

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Bio

George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gdaley?hilite=George+Daley

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=George+Daley

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D

Bio

Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=David+Harlan

Bio

Kevan Herold is the C.N.H. Long Professor of Immunobiology and of Medicine at Yale School of Medicine. He studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy.

Projects

• Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D
• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Kevan+Herold

Bio

Christopher Hughes is a Professor of Molecular Biology and Biochemistry School of Biological Sciences and Professor of Biomedical Engineering at the University of California, Irvine. His lab has identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_chughes?hilite=Chris+Hughes

Projects

• A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
• Modular Monitoring of Hormone Release from Human Islets
• A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

Bio

Albert Hwa is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine.

Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Projects

• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies

Bio

Jeffrey Millman is an Associate Professor of Medicine and Biomedical Engineering at Washington University School of Medicine in St Louis. His research focus is in the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening.

Projects

• Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Bio

Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Audrey+Parent

Bio

Holger Russ is a HIRN New Investigator and recently became an Associate Professor at the University of Florida, Department of Pharmacology and Therapeutics and the Diabetes Institute. His research focuses on using human stem cells to generate novel sources of beta cells for transplantation and to model human T1D in a dish.

HIRN Investigator Profile:

https://hirnetwork.org/profile-rholger

Projects

• Elucidating the Human Beta Cell Translatome in Health and Disease
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Holger+Russ

Bio

Leonard Shultz is a Professor at the Jackson Laboratory. His research leverages immunodeficient mouse models for translational studies on human hematopoiesis, immunity, autoimmunity, infectious diseases, diabetes, regenerative medicine and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lshultz?hilite=Leonard+Shultz

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leonard+Shultz

Bio

Megan Sykes is a Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director, Columbia Center for Translational Immunology. Her research focus is on hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes. The Sykes lab has pioneered minimal conditioning approaches for using HCT to achieve allograft tolerance.

Projects

• Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Megan+Sykes

Bio

Qizhi Tang is a Professor of Transplant Surgery and the Director, Transplantation Research Laboratory at the University of California, San Francisco. Her research focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection.

Projects

• Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs
• Therapeutic Targeting of the Human Islet Environment

Investigator Contributed Resources:

https://www.linkedin.com/in/qizhi-tang-28a0a412/

Bio

Luc Teyton is a Professor in the Department of Immunology and Microbiology at Scripps Research. His research focuses on elucidating the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lteyton?hilite=Luc+Teyton

Projects

• A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

HIRN Webinar:

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D