Projects - HIRN

Gene Therapy for Diabetes View
Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling View
Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells. View
One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery View
Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes View
Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells View

Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity View
Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery View
CAR T Cell Targeting of Human Islets View
Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells View
Epigenetic Rejuvenation of Human Beta-Cells View
In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors View
Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas View
Targeting TXNIP to Enhance Beta Cell Mass in T1D View

Projects - CTAR