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Active Projects
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Gene Therapy for Diabetes
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Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
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Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
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One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery
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Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes
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Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
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Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
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Closed Projects
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Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
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Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
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CAR T Cell Targeting of Human Islets
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Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
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Epigenetic Rejuvenation of Human Beta-Cells
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In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
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Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
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Targeting TXNIP to Enhance Beta Cell Mass in T1D
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