β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

Consortia: CBDS, CTAR

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N, Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B, Dahl-Jørgensen K, Dor Y.
Diabetes. 2018 Aug 27. pii: db171006. doi: 10.2337/db17-1006. PMID: 30150306

All Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation De novo identification of CD4(+) T cell epitopes Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective Interferons are key cytokines acting on pancreatic islets in type 1 diabetes Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis Immuno-Scanning Electron Microscopy of Islet Primary Cilia Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells DNA methylation-based assessment of cell composition in human pancreas and islets A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis Stress and human health in diabetes: A report from the 19(th) Chicago Biomedical Consortium symposium Local dialogues between the endocrine and exocrine cells in the pancreas KD025 is a casein kinase 2 inhibitor that protects against glucolipotoxicity in beta cells SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition NADPH Oxidase 2-Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function Protection of β cells against pro-inflammatory cytokine stress by the GDF15-ERBB2 signaling How to Test Human CAR T Cells in Solid Tumors, the Next Frontier of CAR T Cell Therapy Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes RFX6 maintains gene expression and function of adult human islet α cells Simplified homology-assisted CRISPR for gene editing in Drosophila Genetic risk converges on regulatory networks mediating early type 2 diabetes Beta-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network A proteomic meta-analysis refinement of plasma extracellular vesicles Modulation of insulin secretion by RBFOX2-mediated alternative splicing K(ATP) channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells Checkpoint kinase 2 controls insulin secretion and glucose homeostasis HNF1α maintains pancreatic α and β cell functions in primary human islets Stress-induced β cell early senescence confers protection against type 1 diabetes Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals A bright future for glucagon and alpha cell biology Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity
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