Cystic fibrosis-related diabetes is caused by islet loss and inflammation

Consortia: CBDS, CTAR, HPAC

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.
JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. PMID: 29669939

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Multiplex Generation using Deep Learning Targeting peptide antigens using a multiallelic MHC I-binding system Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells β-Cell gene expression stress signatures in types 1 and 2 diabetes 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides
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Email: hirnec@coh.org