Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells

Consortia: CBDS

Lietzke AC, Walker EM, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D’Ancona E, Henry-Kanarek B, Davidson RK, Li J, Reck EC, Wu Y, Arnipalli M, Pham JP, Mundada L, Sidarala V, Herron TJ, Coronel MM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA.
Nat Commun. 2025 Dec 10;16(1):11037. doi: 10.1038/s41467-025-66022-1. PMID:41372150

Published Works Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04 Lysine Targeting Group-Transfer Chimeras for Proximity Induction Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains Longitudinal monitoring of type 1 diabetes progression to disease onset Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes Persistent urinary metabolic signatures in children with type 1 diabetes Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function DEC1 regulates human β cell functional maturation and circadian rhythm Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity CelLink: integrating single-cell multi-omics data with weak feature linkage and imbalanced cell populations Compressed sensing expands the multiplexity of imaging mass cytometry Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes Metabolic STAMP for deciphering GPCR-regulated insulin secretion by pancreatic β cells Curing autoimmune diabetes in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning A web tool for easy and versatile analysis of human endocrine pancreas single-cell RNAseq data Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy Human NKX2.2 influences islet endocrine cell fate choices through regulation of WNT pathway genes Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes Challenges and Opportunities in State-of-the-Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets A neural entero-pancreatic pathway that regulates insulin secretion and glucose tolerance Proinflammatory Stress Activates Neutral Sphingomyelinase 2-Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation A vascular-associated fibroblastic cell controls pancreatic islet immunity Autoimmune diabetes and targets for immunomodulation Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis Protein carbamylation and proteomics: from artifacts to elucidation of biological functions Histopathology-based protein multiplex generation using deep learning The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell-Derived and Primary Islets Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes The pathophysiology, presentation and classification of Type 1 diabetes The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment-2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals
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