Robust differentiation of human enteroendocrine cells from intestinal stem cells

Consortia: CHIB

Zeve D, Stas E, de Sousa Casal J, Mannam P, Qi W, Yin X, Dubois S, Shah MS, Syverson EP, Hafner S, Karp JM, Carlone DL, Ordovas-Montanes J, Breault DT.
Nat Commun. 2022 Jan 11;13(1):261. doi: 10.1038/s41467-021-27901-5. PMID:35017529

All T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative Bend It Like Occam: Ductal 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