Diverse Routes of Allograft Tolerance Disruption by Memory T Cells

Consortia: CMAI

Gill RG, Burrack AL.
Front Immunol. 2020 Oct 8;11:580483. doi: 10.3389/fimmu.2020.580483. eCollection 2020. PMID:33117387

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Multiplex Generation using Deep Learning Targeting peptide antigens using a multiallelic MHC I-binding system Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells β-Cell gene expression stress signatures in types 1 and 2 diabetes 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides
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