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Publication
04/12/2018

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+Sensitivity of Insulin Secretion Vesicles.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ Jr., Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. 
Dev Cell. 2018 Apr 12. pii: S1534-5807(18)30233-8. PMID: 29656931 

04/17/2018

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.
Mpakali A, Maben Z, Stern LJ, Stratikos E.
Mol Immunol. 2018 Apr 17. pii: S0161-5890(18)30105-6. PMID: 29678301

05/01/2018

Dimensions of immunologic memory. 
Homann D, Kedl RM.
Immunol Rev. 2018 May;283(1):5-6. PMID: 29664575

04/30/2018 Revealing the specificity of regulatory T cells in murine autoimmune diabetes. 
Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JAAnderson MS, Tang Q.
Proc Natl Acad Sci U S A. 2018 Apr 30. pii: 201715590. PMID: 29712852
04/25/2018 Design of a vascularized synthetic poly(ethylene glycol) macroencapsulation device for islet transplantation.
Weaver JD, Headen DM, Hunckler MD, Coronel MM, Stabler CL, García AJ.
2018 Apr 25;172:54-65. doi: 10.1016/j.biomaterials.2018.04.047.PMID: 29715595
11/01/2017

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.
Nathan BM, Boulware D, Geyer S, Atkinson MA, Colman P, Goland R, Russell W, Wentworth JM, Wilson DM, Evans-Molina C, Wherrett D, Skyler JS, Moran A, Sosenko JM; Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.
Diabetes Care. 2017 Nov;40(11):1494-1499. PMID: 28860125

10/01/2017 Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes.
Hanley P, Sutter JA, Goodman NG, Du Y, Sekiguchi DR, Meng W, Rickels MR, Naji A, Luning Prak ET.
Clin Immunol. 2017 Oct;183:336-343. PMID: 28951327
05/15/2018 Genetic Models of Macrophage Depletion.
Hua L, Shi J, Shultz LD, Ren G.
Methods Mol Biol. 2018;1784:243-258. doi: 10.1007/978-1-4939-7837-3_22. PMID: 29761404
05/16/2018 Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.
Greenbaum CJ
, Speake C, Krischer J, Buckner J, Gottlieb PASchatz DAHerold KCAtkinson MA.
Diabetes. 2018 May 16. pii: db180065. PMID: 29769238
05/01/2018 Pancreas regeneration.
Zhou QMelton DA.
Nature. 2018 May;557(7705):351-358. PMID: 29769672
04/30/2018

Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells.
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D’Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.
Transplantation. 2018 Apr 30. doi: 10.1097/TP. PMID: 29781950

05/11/2018

Humanised recombinant antibody fragments bind human pancreatic islet cells.
Buenafe AC, Streeter PR.
J Immunol Methods. 2018 May 11. pii: S0022-1759(18)30068-1. PMID: 29758224

06/01/2018

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance.
James EA, Pietropaolo M, Mamula MJ.
Diabetes. 2018 Jun;67(6):1035-1042. PMID: 29784651

06/01/2018 Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.
Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.
Sci Immunol. 2018 Jun 1;3(24). PMID: 29858286
06/01/2018 Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.
Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M.Cell Stem CellPMID: 29859172
03/29/2018

Establishment of Human Pluripotent Stem Cell-derived Pancreatic β-like cells in the Mouse Pancreas.
Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R.
Proc Natl Acad Sci U S A. 2018 Mar 29. pii: 201702059. PMID: 29599125

04/05/2018

Human MAIT Cells Exit Peripheral Tissues and Recirculate via Lymph in Steady State Conditions
Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR, Prlic M.
JCI Insight. 2018 Apr 5;3(7). pii: 98487.  

03/13/2018

Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation.
Yang B, Patterson NH, Tsui T, Caprioli RMNorris JL.
J Am Soc Mass Spectrom. 2018 Mar 13. doi: 10.1007/s13361-018-1899-9.PMID: 29536413

03/06/2018 Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point.
Rodriguez-Diaz R, Molano RD, Weitz JR, Abdulreda MH, Berman DM, Leibiger B, Leibiger IB, Kenyon NS, Ricordi C, Pileggi A, Caicedo A, Berggren PO.
Cell Metab. 2018 Mar 6;27(3):549-558.e4. doi: 10.1016/j.cmet.2018.01.015. PMID: 29514065
03/01/2018 Signaling between pancreatic β-cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation.
Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y.
J Biol Chem. 2018 Mar 1. pii: jbc.M117.809228. PMID: 29496993
03/02/2018 Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC.
Science. 2018 Mar 2;359(6379):1037-1042.  PMID: 29496879
12/05/2017 MAIT Cells:A Link between Gut Integrity and Type 1 Diabetes.
Gülden E, Palm N, Herold KC.
Cell Metab. 2017 Dec 5;26(6):813-815.PMID: 29211981
11/09/2017 A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.
Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In’t Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
Sci Rep. 2017 Nov 9;7(1):15130. PMID: 29123178
11/28/2017 Combining Machine Learning and Nanofluidic Technology To Diagnose Pancreatic Cancer Using Exosomes.
Ko J, Bhagwat N, Yee SS, Ortiz N, Sahmoud A, Black T, Aiello NM, McKenzie L, O’Hara M, Redlinger C, Romeo J, Carpenter EL, Stanger BZ, Issadore D.
ACS Nano. 2017 Nov 28;11(11):11182-11193. PMID: 29019651
10/03/2016

Advances in β cell replacement and regeneration strategies for treating diabetes
Benthuysen JR, Carrano AC, Sander M.
J Clin Invest. 2016 Oct 3;126(10):3651-3660. doi: 10.1172/JCI87439. Review. PMID: 27694741

09/01/2016 Effects of ageing and senescence on pancreatic β-cell function.

Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, Dor Y.
Diabetes Obes Metab. 2016 Sep;18 Suppl 1:58-62. doi: 10.1111/dom.12719. Review PMID: 27615132

05/10/2016 Generation of stem cell-derived β-cells from patients with type 1 diabetes

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.
Nat Commun. 2016 May 10;7:11463. doi: 10.1038/ncomms11463.  PMID: 27163171

12/01/2015 Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes

Nakayama M, Simmons KM, Michels AW.
Curr Diab Rep. 2015 Dec;15(12):113. doi: 10.1007/s11892-015-0689-z. PMID:26458384

03/02/2015

β cell death and dysfunction during type 1 diabetes development in at-risk individuals
Herold KC, Usmani-Brown S, Ghazi T, Lebastchi J, Beam CA, Bellin MD, Ledizet M, Sosenko JM, Krischer JP, Palmer JP; Type 1 Diabetes TrialNet Study Group..
J Clin Invest. 2015 Mar 2;125(3):1163-73. doi: 10.1172/JCI78142. PMID: 25642774

01/08/2018 Coxsackievirus and Type 1 Diabetes Mellitus: The Wolf’s Footprints
Eizirik DL, Op de Beeck A. Trends
Endocrinol Metab. 2018 Jan 8. pii: S1043-2760(17)30184-4. doi: 10.1016/j.tem.2017.12.002. [Epub ahead of print] PMID: 29326001
12/13/2017 Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas
Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F. Sci Rep. 2017 Dec 13;7(1):17539.  PMID: 29235528
09/14/2017 histoCAT: Analysis of Cell Phenotypes and Interactions in Multiplex Image Cytometry Data
Schapiro D, Jackson HW, Raghuraman S, Fischer JR, Zanotelli VRT, Schulz D, Giesen C, Catena R, Varga Z, Bodenmiller B. Nat Methods. 2017 Sep;14(9):873-876. PMID: 28783155
12/13/2017 Growth hormone and insulin-like growth factor-I axis in type 1 diabetes
Nambam B, Schatz D.
Growth Horm IGF Res. 2017 Dec 13. pii: S1096-6374(17)30114-4. PMID: 29249623
07/06/2016 The Genetic Landscape of β-Cell Proliferation: Toward a Road Map
Wagner BK
Diabetes. 2016 Jul;65(7):1789-90.  PMID: 27329954
09/25/2017 The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression

Semeraro ML, Glenn LM, Morris MA.
Front Endocrinol (Lausanne). 2017 Sep 25;8:246. PMID: 28993759

02/09/2017 Regenerative Medicine: Interspecies Pancreas Transplants
Zhou Q.
Nature. 2017 Feb 9;542(7640):168-169. PMID: 28179664
02/02/2017 Reprogramming of Pancreatic Acinar Cells to Functional Beta Cells by In Vivo Transduction of a Polycistronic Construct Containing Pdx1, Ngn3, MafA in Mice
Cavelti-Weder C, Zumsteg A, Li W, Zhou Q.
Curr Protoc Stem Cell Biol. 2017 Feb 2;40:4A.10.1-4A.10.12. doi: 10.1002/cpsc.21. PMID: 28152182
12/20/2017 Extracellular matrix hydrogel therapies: in vivo applications and development
Spang MT, Christman KL. Acta Biomater. 2017 Dec 20. pii: S1742-7061(17)30785-7. doi: 10.1016/j.actbio.2017.12.019.
PMID: 29274480
12/18/2017 C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes
Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai
S. Proc Natl Acad Sci U S A. 2017 Dec 18. pii: 201716527. doi: 10.1073/pnas.1716527115. PMID: 29255035
12/05/2017

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Burrack AL, Martinov T, Fife BT.
Front. Endocrinol., 05 December 2017. doi. 10.3389

12/14/2017

Understanding Autoimmune Diabetes through the Prism of Tri-Molecular Complex
Bettini ML, Bettini M.
Front Endocrinol., 14 December 2017. doi. 10.3389

12/11/2017 Oxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle HA, Clarke SG, Herold KC, Mamula MJ.

Antioxid Redox Signal. 2017 Dec 11. doi: 10.1089/ars.2017.7382. [Epub ahead of print] PMID: 29088923

12/08/2017 Deep Tissue Optical Focusing and Optogenetic Modulation with Time-reversed Ultrasonically Encoded Light

Ruan H, Brake J, Robinson JE, Liu Y, Jang M, Xiao C, Zhou C, Gradinaru V, Yang C.
Sci Adv. 2017 Dec 8;3(12):eaao5520. doi: 10.1126/sciadv.aao5520. eCollection 2017 Dec. PMID: 29226248

12/05/2017 Science Forum: The Human Cell Atlas

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim SK, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe’er D, Phillipakis A, Ponting CP, Quake SR, Reik W, Rozenblatt-Rosen O, Sanes JR, Satija R, Schumacher TN, Shalek AK, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton MR, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt FM, Weissman JS, Wold BJ, Xavier RJ, Yosef N; Human Cell Atlas Meeting Participants.
Elife. 2017 Dec 5;6. pii: e27041. PMID: 29206104

05/08/2017

The Human Cell Atlas
Aviv Regev, Sarah Teichmann, Eric S. Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Gottgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung K. Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Joakim Lundeberg, Partha Majumder, John Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe’er, Anthony Philipakis, Chris P. Ponting, Stephen R. Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua R. Sanes, Rahul Satija, Ton Shumacher, Alex K. Shalek, Ehud Shapiro, Padmanee Sharma, Jay Shin, Oliver Stegle, Michael Stratton, Michael J. T. Stubbington, Alexander van Oudenaarden, Allon Wagner, Fiona M. Watt, Jonathan S. Weissman, Barbara Wold, Ramnik J. Xavier, Nir Yosef, Human Cell Atlas Meeting Participants.
bioRxiv 121202; doi: https://doi.org/10.1101/121202

11/11/2017

Hospital time prior to death and pancreas histopathology: implications for future studies Kusmartseva I, Beery M, Philips T, Selman S, Jadhav P, Wasserfall C, Muller A, Pugliese A, Longmate JA, Schatz DAAtkinson MAKaddis JS.
Diabetologia. 2017 Nov 11. doi: 10.1007/s00125-017-4494-x. PMID: 29128936

09/01/2017

High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 DiabetesZ
Jacobsen LM, Haller MJ, Parish A, Gurka MJ, Levine SR, Wasserfall C, Campbell-Thompson M, Kaddis J, Pugliese A, Atkinson MA, Schatz DA.
Diabetes Care. 2017 Sep;40(9):e122-e123. PMID: 28679687

12/01/2017

Tolerance in Xenotransplantation
Yamada K, Sykes M, Sachs DH.
Curr Opin Organ Transplant. 2017 Dec;22(6):522-528. PMID: 28937406

11/06/2017 Genome-wide Genetic and Epigenetic Analyses of Pancreatic Acinar Cell Carcinomas Reveal Aberrations in Genome Stability
Jäkel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, Hank T, Klöppel G, Dorrell C, Grompe M, Moss J, Dor Y, Schirmacher P, Plass C, Popanda O, Schmezer P.

Nat Commun. 2017 Nov 6;8(1):1323. PMID: 29109526

11/08/2017 LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers
Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG 2nd, Qian WJ.
Methods Mol Biol. 2017 Nov 8. doi: 10.1007/7651_2017_93. PMID: 29116567
11/09/2017 A nanobody-based Tracer Targeting DPP6 for Non-invasive Imaging of Human Pancreatic Endocrine Cells
Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In’t Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
Sci Rep. 2017 Nov 9;7(1):15130. PMID: 29123178
11/01/2015 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA.
Diabetes. 2015 Nov;64(11):3873-84. PMID: 26185279 
08/01/2016 Gestational Diabetes Mellitus from Inactivation of Prolactin Receptor and MafB in Islet β-Cells
Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK.
Diabetes. 2016 Aug;65(8):2331-41. PMID: 27217483
02/01/2016 Research Resource: Genetic Labeling of Human Islet Alpha Cells
Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK.
Mol Endocrinol. 2016 Feb;30(2):248-53. PMID: 26745668
10/31/2017 Oxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle H, Clarke SG, Herold KMamula M.
Antioxid Redox Signal. 2017 Oct 31. doi: 10.1089/ars.2017.7382. PMID: 29088923
10/25/2017 Immunoisolation of Murine Islet Allografts in Vascularized Sites Through Conformal Coating with Polyethylene Glycol
Manzoli V, Villa C, Bayer AL, Morales L, Molano RD, Torrente Y, Ricordi C, Hubbell JA, Tomei AA.
Am J Transplant. 2017 Oct 25. doi: 10.1111/ajt.14547. PMID: 2906814
09/25/2017 Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity

Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA.
Mol Ther. 2017 Sep 25. pii: S1525-0016(17)30437-9. PMID: 29055620

10/27/2017 PLATO Software Provides Analytic Framework for Investigating Complexity beyond Genome-wide Association Studies
Hall MA, Wallace J, Lucas A, Kim D, Basile AO, Verma SS, McCarty CA, Brilliant MH, Peissig PL, Kitchner TE, Verma A, Pendergrass SA, Dudek SM, Moore JH, Ritchie MD.
Nat Commun. 2017 Oct 27;8(1):1167. PMID: 29079728
10/15/2017 Tissue-specific network-based genome wide study of amygdala imaging phenotypes to identify functional interaction modules
Yao X, Yan J, Liu K, Kim S, Nho K, Risacher SL, Greene CS, Moore JH, Saykin AJ, Shen L; Alzheimer’s Disease Neuroimaging Initiative.
Bioinformatics. 2017 Oct 15;33(20):3250-3257. PMID: 28575147
10/19/2017 Cytoplasmic Chromatin Triggers Inflammation in Senescence and Cancer
Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.
Nature. 2017 Oct 19;550(7676):402-406. PMID: 28976970
03/07/2017 Enhanced Spatially Resolved Proteomics Using On-Tissue Hydrogel-Mediated Protein Digestion
Rizzo DG, Prentice BM, Moore JL, Norris JL, Caprioli RM.
Anal Chem. 2017 Mar 7;89(5):2948-2955. PMID: 28193007
02/07/2017 ATF5 Regulates β-cell Survival During Stress

Juliana CA, Yang J, Rozo AV, Good A, Groff DN, Wang SZ, Green MR, Stoffers DA.
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1341-1346. PMID: 28115692

01/06/2016 Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays

Bian X, Wasserfall C, Wallstrom G, Wang J, Wang H, Barker K, Schatz D, Atkinson M, Qiu J, LaBaer J.
J Proteome Res. 2017 Jan 6;16(1):195-203. PMID: 27690455

09/29/2017 Kinetics of Functional Beta Cell Mass Decay in a Diphtheria Toxin Receptor Mouse Model of Diabetes
van Krieken PP, Dicker A, Eriksson M, Herrera PL, Ahlgren U, Berggren PO, Ilegems E.

Sci Rep. 2017 Sep 29;7(1):12440. PMID: 28963457

10/19/2017 T Cells Expressing Chimeric Antigen Receptor Promote Immune Tolerance
Pierini A, Iliopoulou BP, Peiris H, Pérez-Cruz M, Baker J, Hsu K, Gu X, Zheng PP, Erkers T, Tang SW, Strober W, Alvarez M, Ring A, Velardi A, Negrin RS, Kim SK, Meyer EH.
JCI Insight. 2017 Oct 19;2(20). PMID: 29046484
10/23/2017 EGFR Signalling Controls Cellular Fate and Pancreatic Organogenesis by Regulating Apicobasal Polarity
Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H.
Nat Cell Biol. 2017 Oct 23. PMID: 29058721
07/01/2016 The Genetic Landscape of β-Cell Proliferation: Toward a Road Map

Wagner BK.
Diabetes. 2016 Jul;65(7):1789-90. PMID: 27329954

06/01/2016

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RNWagner BK.
Diabetes. 2016 Jun;65(6):1660-71. PMID:26953159 

04/26/2017 Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities
Roybal KT, Lim WA.
Annu Rev Immunol. 2017 Apr 26;35:229-253. doi: 10.1146/annurev-immunol-051116-052302. PMID: 28446063
10/15/2017 Tissue-specific network-based genome wide study of amygdala imaging phenotypes to identify functional interaction modules
Yao X, Yan J, Liu K, Kim S, Nho K, Risacher SL, Greene CS, Moore JH, Saykin AJ, Shen L; Alzheimer’s Disease Neuroimaging Initiative.
Bioinformatics. 2017 Oct 15;33(20):3250-3257. doi: 10.1093/bioinformatics/btx344. PMID: 28575147
10/12/2017 Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes
Newman JRB, Conesa A, Mika M, New FN, Onengut-Gumuscu S, Atkinson MA, Rich SS, McIntyre LM, Concannon P.
Genome Res. 2017 Oct 12. doi: 10.1101/gr.217984.116. PMID: 29025893
10/11/2017 T Cell Receptor Profiling in Type 1 Diabetes
Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM.
Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Review. PMID: 29022222
10/06/2017 Comprehensive Metabolomics Study To Assess Longitudinal Biochemical Changes and Potential Early Biomarkers in Nonobese Diabetic Mice That Progress to Diabetes
Buchwald P, Tamayo-Garcia A, Ramamoorthy S, Garcia-Contreras M, Mendez AJ, Ricordi C.
J Proteome Res. 2017 Oct 6;16(10):3873-3890. doi: 10.1021/acs.jproteome.7b00512. Epub 2017 Aug 29. PMID: 28799767
09/11/2017

A Radial Axis defined by Semaphorin to Neuropilin signaling controls pancreatic islet morphogenesis
Pauerstein PT, Tellez K, Willmarth KB, Park KM, Hsueh B, Arda HE, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SK.
Development. 2017 Sep 11. pii: dev.148684. doi: 10.1242/dev.148684. PMID: 28893946

05/31/2017

Epigenetics in Formation, Function, and Failure of the Endocrine pPancreas
Golson ML,Kaestner KH.
Mol Metab. 2017 May 31;6(9):1066-1076. doi: 10.1016/j.molmet.2017.05.015. eCollection 2017 Sep. Review. PMID: 28951829

09/25/2017 Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology?

Greenbaum A, Jang MJ, Challis C, Gradinaru V.
BMC Biol. 2017 Sep 25;15(1):87. doi: 10.1186/s12915-017-0421-3. PMID: 28946882

07/08/2017 Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

Chen C, Cohrs CM, Stertmann J, Bozsak R, Speier S.
Mol Metab. 2017 Jul 8;6(9):943-957. doi: 10.1016/j.molmet.2017.06.019. eCollection 2017 Sep. Review. PMID: 28951820

07/20/2017 Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas

Tritschler S, Theis FJ, Lickert H, Böttcher A.
Mol Metab. 2017 Jul 20;6(9):974-990. doi: 10.1016/j.molmet.2017.06.021. eCollection 2017 Sep. Review. PMID: 28951822

05/05/2017 Interrogating islets in health and disease with single-cell technologies

Carrano AC, Mulas F, Zeng C, Sander M.
Mol Metab. 2017 May 5;6(9):991-1001. doi: 10.1016/j.molmet.2017.04.012. eCollection 2017 Sep. Review. PMID: 28951823

09/29/2017 Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes

van Krieken PP, Dicker A, Eriksson M, Herrera PL, Ahlgren U, Berggren PO, Ilegems E.
Sci Rep. 2017 Sep 29;7(1):12440. doi: 10.1038/s41598-017-12124-w. PMID: 28963457

03/03/2016

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation
Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q.
Cell Stem Cell. 2016 Mar 3;18(3):410-21. doi: 10.1016/j.stem.2016.01.003. Epub 2016 Feb 18. PMID: 26908146

09/19/2017 Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
Larsen HL, Martín-Coll L, Nielsen AV, Wright CVE, Trusina A, Kim YH, Grapin-Botton A.
Nat Commun. 2017 Sep 19;8(1):605. doi: 10.1038/s41467-017-00258-4. PMID: 28928395
09/19/2017

Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform
Wan H, Merriman C, Atkinson MA, Wasserfall CH, Mcgrail KM, Liang Y, Fu D, Dai H.
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10196-10201. doi: 10.1073/pnas.1711169114. Epub 2017 Sep 5. PMID: 28874568

09/11/2017

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development
Yu H, Gagliani N, Ishigame H, Huber S, Zhu S, Esplugues E, Herold KC, Wen L, Flavell RA.
Proc Natl Acad Sci U S A. 2017 Sep 11. pii: 201705599. doi: 10.1073/pnas.1705599114. [Epub ahead of print] PMID: 28894001

09/07/2017 Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity
Weitz JR, Makhmutova M, Almaça J, Stertmann J, Aamodt K, Brissova M, Speier S, Rodriguez-Diaz R, Caicedo A.
Diabetologia. 2017 Sep 7. doi: 10.1007/s00125-017-4416-y. [Epub ahead of print] PMID: 28884198
02/22/2017 A Divergent Population of Autoantigen-responsive CD4+ T cells in infants prior to β cell autoimmunity

Heninger AK, Eugster A, Kuehn D, Buettner F, Kuhn M, Lindner A, Dietz S, Jergens S, Wilhelm C, Beyerlein A, Ziegler AG, Bonifacio E.
Sci Transl Med. 2017 Feb 22;9(378). pii: eaaf8848. doi: 10.1126/scitranslmed.aaf8848. PMID: 28228602

08/31/2017

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes
Dirice E, Ng R, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BKKulkarni RN.
J Biol Chem. 2017 Aug 31. pii: jbc.M117.804328. doi: 10.1074/jbc.M117.804328. [Epub ahead of print] PMID: 28860191

09/05/2017

Targeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets
Yu Q, Canales A, Glover MS, Das R, Shi X, Liu Y, Keller MP, Attie AD, Li L.
Anal Chem. 2017 Sep 5;89(17):9184-9191. doi: 10.1021/acs.analchem.7b01926. Epub 2017 Aug 7. PMID: 28726377

08/16/2017

Reprogramming human gallbladder cells into insulin-producing β-like cells
Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KHGrompe M.
PLoS One. 2017 Aug 16;12(8):e0181812. doi: 10.1371/journal.pone.0181812. eCollection 2017. PMID: 28813430

08/30/2017 Discovery of stimulation-responsive immune enhancers with CRISPR activation

Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MSBluestone JA, Chang HY, Corn JE, Marson A.
Nature. 2017 Aug 30. doi: 10.1038/nature23875. [Epub ahead of print] PMID: 28854172

09/13/2017 β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?
Rodriguez-Calvo T, Atkinson M, von Herrath M.
Nat Rev Endocrinol. 2017 Sep;13(9):1. doi: 10.1038/nrendo.2017.83. Epub 2017 Jul 7. No abstract available. PMID: 28685769
08/25/2016 Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

Seyhan AA, Nunez Lopez YO, Xie H, Yi F, Mathews C, Pasarica M, Pratley RE.
Sci Rep. 2016 Aug 25;6:31479. doi: 10.1038/srep31479. PMID: 27558530

06/30/2017

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells
Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.
Diabetes.2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30. PMID: 28667119

08/02/2017

Understanding and preventing type 1 diabetes through the unique working model of TrialNet
Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M.
Diabetologia. 2017 Aug 2. doi: 10.1007/s00125-017-4384-2. [Epub ahead of print] Review. PMID: 28770323

08/18/2017 Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes
Yip L, Fuhlbrigge R, Atkinson MA, Fathman CG.
BMC Genomics. 2017 Aug 18;18(1):636. doi: 10.1186/s12864-017-3949-2. PMID: 28821222
08/16/2017

Regenerative medicine and cell-based approaches to restore pancreatic function
Ellis C, Ramzy A, Kieffer TJ.
Nat Rev Gastroenterol Hepatol. 2017 Aug 16. doi: 10.1038/nrgastro.2017.93. [Epub ahead of print] Review. PMID: 28811674

02/23/2017

Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
Erener S, Marwaha A, Tan R, Panagiotopoulos C, Kieffer TJ.
JCI Insight. 2017 Feb 23;2(4):e89656. doi: 10.1172/jci.insight.89656. PMID: 28239651

03/17/2017

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue
Vallabhajosyula P, Korutla L, Habertheuer A, Yu M, Rostami S, Yuan CX, Reddy S, Liu C, Korutla V, Koeberlein B, Trofe-Clark J, Rickels MR, Naji A.
J Clin Invest. 2017 Apr 3;127(4):1375-1391. doi: 10.1172/JCI87993. Epub 2017 Mar 20. PMID: 28319051

08/07/2017

Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.
Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA.
ACS Nano. 2017 Aug 7. doi: 10.1021/acsnano.7b01239. [Epub ahead of print] PMID: 28763191

07/07/2017

Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass
Shirakawa J, De Jesus DF, Kulkarni RN.
Eur J Clin Nutr. 2017 Jul;71(7):896-903. doi: 10.1038/ejcn.2017.13. Epub 2017 Mar 15. Review. PMID: 28294170

07/21/2017

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus.
Garcia-Contreras M, Brooks RW, Boccuzzi L, Robbins PD, Ricordi C.
Eur Rev Med Pharmacol Sci. 2017 Jun;21(12):2940-2956. PMID: 28682421

07/11/2017

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladriere L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.
J Biol Chem. 2017 Jul 11. pii: jbc.M116.769877. doi: 10.1074/jbc.M116.769877. [Epub ahead of print] PMID: 28698383

07/31/2017

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression
Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, Fousteri G, Brusko TM, Dotta F, Battaglia M.
Sci Rep2017 Jul 31;7(1):6897. doi: 10.1038/s41598-017-07172-1.PMID: 28761107

08/08/2017 Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q.
Stem Cell Reports. 2017 Aug 8. pii: S2213-6711(17)30322-3. doi: 10.1016/j.stemcr.2017.07.012. PMID: 28803916
08/11/2017 A Comprehensive Metabolomics Study to Assess Longitudinal Biochemical Changes and Potential Early Biomarkers in NOD Mice that Progress to Diabetes
Buchwald P
, Tamayo-Garcia A, Ramamoorthy S, Garcia-Contreras M, Mendez AJ, Ricordi C.
J Proteome Res. 2017 Aug 11. doi: 10.1021/acs.jproteome.7b00512. [Epub ahead of print] PMID: 28799767
07/20/2017

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes
Garcia-Contreras M, Shah SH, Tamayo A, Robbins PD, Golberg RB, Mendez AJ, Ricordi C.
Sci Rep. 2017 Jul 20;7(1):5998. doi: 10.1038/s41598-017-05787-y. PMID: 28729721

07/19/2017

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease
Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang AC, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, Efimov IR, Kim S, Deisseroth
Scientific Reports. 7, Article number” 5899 (2017) doi:10.1038/s41598-017-05614-4

06/01/2017

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
O’Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA, Atkinson MA.
Diabetes. 2017 Jun;66(6):1443-1452. doi: 10.2337/db16-1551. PMID: 28533295

05/01/2017 Gotta Have GATA for Human Pancreas Development
Lorberbaum DS, Sussel L.

Cell Stem Cell. 2017 May 4;20(5):577-579. doi: 10.1016/j.stem.2017.04.004. PMID: 28475878

06/01/2015 Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α

Ocaña GJ, Pérez L, Guindon L, Deffit SN, Evans-Molina C, Thurmond DC, Blum JS.
Immunology. 2017 Jun;151(2):198-210. doi: 10.1111/imm.12723. Epub 2017 Mar 13. PMID: 28190264

04/04/2017 Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR.
Cell Metab. 2017 Apr 4;25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018. PMID: 28380378
05/02/2017

Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation
Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M.
Cell Metab. 2017 May 2;25(5):1160-1175.e11. doi: 10.1016/j.cmet.2017.04.014. PMID: 28467932

05/13/2017

Clinical pancreatic islet transplantation
Shapiro AM, Pokrywczynska M, Ricordi C.
Nat Rev Endocrinol. 2017 May;13(5):268-277. doi: 10.1038/nrendo.2016.178. Epub 2016 Nov 11. Review. PMID: 27834384

06/01/2017

Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial
Coronel MM, Geusz R, Stabler CL.
Biomaterials. 2017 Jun;129:139-151. doi: 10.1016/j.biomaterials.2017.03.018. Epub 2017 Mar 18. PMID: 28342320

01/31/2017

Insulin and Glucagon: Partners for Life
Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL.
Endocrinology. 2017 Jan 31. doi: 10.1210/en.2016-1748. [Epub ahead of print] PMID: 28323959

04/04/2017

Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets
van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO.
Cell Metab. 2017 Apr 4;25(4):911-926.e6. doi: 10.1016/j.cmet.2017.03.017. PMID: 28380380

02/01/2017

All mixed up: defining roles for β-cell subtypes in mature islets
Liu JS, Hebrok M.
Genes Dev. 2017 Feb 1;31(3):228-240. doi: 10.1101/gad.294389.116. Review. PMID: 28270515

02/07/2017

Designing β Cells
Hebrok M.
Cell Metab. 2017 Feb 7;25(2):223-224. doi: 10.1016/j.cmet.2017.01.018. PMID: 28178560

01/12/2017

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KV, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, Kubicek S.
Cell. 2017 Jan 12;168(1-2):86-100.e15. doi: 10.1016/j.cell.2016.11.010. PMID: 27916275

09/01/2016

β-Cell replacement as a treatment for type 1 diabetes: an overview of possible cell sources and current axes of research.
Vieira A, Courtney M, Druelle N, Avolio F, Napolitano T, Hadzic B, Navarro-Sanz S, Ben-Othman N, Collombat P.
Diabetes Obes Metab. 2016 Sep;18 Suppl 1:137-43. doi: 10.1111/dom.12721. Review. PMID: 27615143

11/01/2016

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease
Ziegler AG, Bonifacio E, Powers AC, Todd JA, Harrison LC, Atkinson MA.
Diabetes. 2016 Nov;65(11):3233-3239. PMID:27959859

01/01/2017

Future of rAAV gene therapy: Platform for RNAi, Gene Editing and Beyond
Valdmanis P, Kay MA.
Hum Gene Ther. 2017 Jan 10. doi: 10.1089/hum.2016.171.

01/03/2017

β Cells led astray by transcription factors and the company they keep
Thompson P, Bhushan A. J Clin Invest. 2017 Jan 3;127(1):94-97. doi: 10.1172/JCI91304. PMID: 27941244

05/01/2016

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
Dhawan S, Dirice E, Kulkarni RN, Bhushan A.
Diabetes. 2016 May;65(5):1208-18. doi: 10.2337/db15-1331. PMID: 26936960

01/23/2017

Serum Trypsinogen Levels in Type 1 Diabetes
Li X,Campbell-Thompson M, Wasserfall CH, McGrail K, Posgai A, Schultz AR, Brusko TM, Shuster J, Liang F, Muir A, Schatz D, Haller MJ, Atkinson MA.
Diabetes Care. 2017 Jan 23. pii: dc161774. doi: 10.2337/dc16-1774. [Epub ahead of print] PMID: 28115475

06/21/2016

Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2
Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ.
Sci Signal. 2016 Jun 21;9(433):ra61. doi: 10.1126/scisignal.aad0612. PMID: 27330188

12/05/2016

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials
Esensten JH, Bluestone JA, Lim WA.
Annu Rev Pathol. 2016 Dec 5. [Epub ahead of print] PMID: 27959633

12/28/2016

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J.
Cell Metab. 2016 Dec 28. pii: S1550-4131(16)30595-2. PMID: 28041957

01/01/2017

Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research
Burke GW 3rd, Posgai AL, Wasserfall CH, Atkinson MA, Pugliese A.
Am J Transplant. 2017 Jan;17(1):306-307. doi: 10.1111/ajt.13983. No abstract available. PMID: 27460917

01/01/2017

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity
Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.
Diabetologia. 2017 Jan;60(1):35-38. PMID: 27785529

12/12/2016

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.
Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA.
J Clin Invest. 2016 Dec 12. pii: 88016. doi: 10.1172/JCI88016. [Epub ahead of print] MID: 27941246

12/12/2016

Pancreatic β cell identity requires continual repression of non-β cell programs
Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L.
J Clin Invest. 2016 Dec 12. pii: 88017. doi: 10.1172/JCI88017. [Epub ahead of print] PMID: 27941248

11/11/2016

Clinical pancreatic islet transplantation
Shapiro AM, Pokrywczynska M, Ricordi C.
Nat Rev Endocrinol. 2016 Nov 11. doi: 10.1038/nrendo.2016.178. [Epub ahead of print] Review. PMID: 7834384

10/27/2016

Efficient generation of pancreatic β-like cells from the mouse gallbladder
Wang Y, Galivo F, Pelz C, Haft A, Lee J, Kim SKGrompe M.
Stem Cell Res. 2016 Oct 27;17(3):587-596. doi: 10.1016/j.scr.2016.10.009.  PMID: 27833043

10/26/2016

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I.
Cell Syst 2016 Oct 26;3(4):346-360.e4. doi: 10.1016/j.cels.2016.08.011. PMID: 27667365

10/26/2016

Surprising Heterogeneity of Pancreatic Islet Cell Subsets
Blodgett DM, Redick SD, Harlan DM.
Cell Syst 2016 Oct 26;3(4):330-332. doi: 10.1016/j.cels.2016.10.009. PMID: 27788358

10/26/2016

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity 
Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.
Diabetologia2016 Oct 26. [Epub ahead of print] PMID: 27785529

10/26/2016

Surprising Heterogeneity of Pancreatic Islet Cell Subsets 
Blodgett DM, Redick SD, Harlan DM.
Cell Syst 2016 Oct 26;3(4):330-332. doi: 10.1016/j.cels.2016.10.009. PMID: 27788358

10/24/2016

Vascular development in the vertebrate pancreas
Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, Marty-Santos L, Fu S, Dor Y, Cleaver O.
Dev Biol. 2016 Oct 24. pii: S0012-1606(16)30428-6. doi: 10.1016/j.ydbio.2016.10.009.  PMID: 27789228

08/01/2016

Genome therapy of myotonic dystrophy type 1 iPS cells for development of autologous stem cell therapy 
Gao Y, Guo X, Santostefano KE, Wang Y. Reid T, Zeng D, Terada N, Ashizawa T, Xia G.   Mol. Ther. 24:1378-87, Aug, 2016 PMID: 27203440

08/01/2016

DNA Damage and Aging Around the Clock
Gutierrez-Martinez P, Rossi DJ, Beerman I.
Trends Mol Med. 2016 Aug;22(8):635-7. doi: 10.1016/j.molmed.2016.06.006. Epub 2016 Jun 23. PMID: 27345866

07/09/2016

Mutant IDH1 Downregulates and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2 
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M,
Rossi DJ, Nolan GP, Cairns RA, Mak TW.
Cancer Cell. 2016 Jul 9. [Epub ahead of print] PMID: 27424808. [PMCID in process].

06/06/2016

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Nature Biotechnology. 2016 Jun 6. [Epub ahead of print] PMID: 27272386. 

04/01/2016

Developing Drosopila to discover the hormonal orgins of type 2 diabetes mellitus 
R. Alfa, S. Kim
Dis Model Mech. 2016 Apr 1;9(4):365-76. doi: 10.1242/dmm.023887

03/29/2016

Mitotic history reveals distinct stem cell populations and their contributions to hematopoiesis
Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D.
Cell Reports. Epub 2017 Mar 17. doi:10.1016/j.celrep.2016.02.073

12/15/2015

Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes
Nakayama M, Simmons KM, Michels AW.
Curr Diab Rep. 2015 Dec;15(12):113. doi: 10.1007/s11892-015-0689-z. Review. PMID: 26458384

12/01/2015

Vascular smooth muscle cells from hypertensive patient-derived induced pluripotent stem cells to advance hypertension pharmacogenomics 
Biel NM, Santostefano KE, DiVita BB, El Rouby N, Carrasquillas S, Simmons C, Nakanishi M, Cooper-DeHoff RM, Johnson JA, Terada N
Stem Cells Transl. Med. 4:1380-90, Dec, 2015  PMCID: 4675511

11/20/2015

Humanized Mouse Models for Transplant Immunology
Kenney LL, Shultz LD, Greiner DL, Brehm MA.
Am J Transplant. 2016 Feb;16(2):389-97. doi: 10.1111/ajt.13520. Epub 2015 Nov 20.  PMID: 26588186

10/01/2015

Directed differentiation of embryonic stem cells into cardiomyocytes by bacterial injection of defined transcriptional factors 
Bai F, Lim CH, Jia J, Santostefano KE, Simmons C, Kasahara H, Terada N, Jin S
Sci. Rep. 5:15014, Oct, 2015 PMCID:  4511150

08/01/2015

Efficient gene editing in pluripotent stem cells by bacterial injection of TALEN proteins
Jia J, Bai F, Santostefano KE, Wu D, Wu W, Terada N, Jin S
Stem Cells Transl. Med. 4:913-26, Aug, 2015  PMCID:4598736

06/10/2014

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells
Marroqui L, Lopes M, dos Santos R, Grieco F, Roivainen M, Richardson SJ, Morgan NG, de beeck AO, Eizirik D.
ELife. 2015 Jun 10;4:e06990. doi: 10.7554/eLife.06990.