The physiological role of β-cell heterogeneity in pancreatic islet function

Benninger RKP, Kravets V.
Nat Rev Endocrinol. 2021 Oct 19. doi: 10.1038/s41574-021-00568-0. Online ahead of print. PMID:34667280

Of Interest Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Deep Visual Proteomics defines single-cell identity and heterogeneity Modular design of synthetic receptors for programmed gene regulation in cell therapies Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8 New insights into β-cell failure, regeneration and replacement Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation Using the T Cell Receptor as a Biomarker in Type 1 Diabetes Pancreatic islets in bed with microvasculature-companions for life Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium α-cell Gq signaling is critical for maintaining euglycemia A human ESC line for efficient CRISPR editing of pluripotent stem cells The physiological role of β-cell heterogeneity in pancreatic islet function Mutations and variants of ONECUT1 in diabetes Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes SARS-CoV-2 infection of islet β cells: Evidence and implications Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Engineering islets from stem cells for advanced therapies of diabetes Generation of insulin-producing pancreatic β cells from multiple human stem cell lines Defining a cure for type 1 diabetes: a call to action Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes Immunotherapy: Building a bridge to a cure for type 1 diabetes Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma Uncovering Pathways to Personalized Therapies in Type 1 Diabetes Stem Cell-Based Clinical Trials for Diabetes Mellitus T cell circuits that sense antigen density with an ultrasensitive threshold HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing T cells selectively filter oscillatory signals on the minutes timescale Comprehensive analysis of single cell ATAC-seq data with SnapATAC The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes Current and future therapies for type 1 diabetes Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
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