The Integrated Islet Distribution Program answers the call for improved human islet phenotyping and reporting of human islet characteristics in research articles

Brissova M, Niland JC, Cravens J, Olack B, Sowinski J, Evans-Molina C.
Diabetologia. 2019 May 15. doi: 10.1007/s00125-019-4876-3. PMID:31089753

Of Interest Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways Identifying type 2 diabetes risk genes by β-cell CRISPR screening Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Deep Visual Proteomics defines single-cell identity and heterogeneity Modular design of synthetic receptors for programmed gene regulation in cell therapies Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8 New insights into β-cell failure, regeneration and replacement Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation Using the T Cell Receptor as a Biomarker in Type 1 Diabetes Pancreatic islets in bed with microvasculature-companions for life Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium α-cell Gq signaling is critical for maintaining euglycemia A human ESC line for efficient CRISPR editing of pluripotent stem cells The physiological role of β-cell heterogeneity in pancreatic islet function Mutations and variants of ONECUT1 in diabetes Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes SARS-CoV-2 infection of islet β cells: Evidence and implications Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Engineering islets from stem cells for advanced therapies of diabetes Generation of insulin-producing pancreatic β cells from multiple human stem cell lines Defining a cure for type 1 diabetes: a call to action Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes Immunotherapy: Building a bridge to a cure for type 1 diabetes Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
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