Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells

Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA.
Mol Metab. 2019 May 24. pii: S2212-8778(19)30470-3. doi: 10.1016/j.molmet.2019.05.009. PMID:31178390

Of Interest IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Deep Visual Proteomics defines single-cell identity and heterogeneity Modular design of synthetic receptors for programmed gene regulation in cell therapies Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8 New insights into β-cell failure, regeneration and replacement Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation Using the T Cell Receptor as a Biomarker in Type 1 Diabetes Pancreatic islets in bed with microvasculature-companions for life Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium α-cell Gq signaling is critical for maintaining euglycemia A human ESC line for efficient CRISPR editing of pluripotent stem cells The physiological role of β-cell heterogeneity in pancreatic islet function Mutations and variants of ONECUT1 in diabetes Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes SARS-CoV-2 infection of islet β cells: Evidence and implications Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Engineering islets from stem cells for advanced therapies of diabetes Generation of insulin-producing pancreatic β cells from multiple human stem cell lines Defining a cure for type 1 diabetes: a call to action Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes Immunotherapy: Building a bridge to a cure for type 1 diabetes Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma Uncovering Pathways to Personalized Therapies in Type 1 Diabetes Stem Cell-Based Clinical Trials for Diabetes Mellitus T cell circuits that sense antigen density with an ultrasensitive threshold HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing T cells selectively filter oscillatory signals on the minutes timescale Comprehensive analysis of single cell ATAC-seq data with SnapATAC The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes Current and future therapies for type 1 diabetes Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion A little help from residual β cells has long-lasting clinical benefits PDX1(LOW) MAFA(LOW) β-cells contribute to islet function and insulin release
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