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- Consortium on Beta Cell Death and Survival (CBDS)
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Of Interest
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Deep Visual Proteomics defines single-cell identity and heterogeneity
Modular design of synthetic receptors for programmed gene regulation in cell therapies
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
New insights into β-cell failure, regeneration and replacement
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
Pancreatic islets in bed with microvasculature-companions for life
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
α-cell Gq signaling is critical for maintaining euglycemia
A human ESC line for efficient CRISPR editing of pluripotent stem cells
The physiological role of β-cell heterogeneity in pancreatic islet function
Mutations and variants of ONECUT1 in diabetes
Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells
CD8(+) T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
SARS-CoV-2 infection of islet β cells: Evidence and implications
Engineering islets from stem cells for advanced therapies of diabetes
Generation of insulin-producing pancreatic β cells from multiple human stem cell lines
Defining a cure for type 1 diabetes: a call to action
Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes
Immunotherapy: Building a bridge to a cure for type 1 diabetes
Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes
Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR
Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Uncovering Pathways to Personalized Therapies in Type 1 Diabetes
Stem Cell-Based Clinical Trials for Diabetes Mellitus
T cell circuits that sense antigen density with an ultrasensitive threshold
Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing
HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes
T cells selectively filter oscillatory signals on the minutes timescale
Comprehensive analysis of single cell ATAC-seq data with SnapATAC
The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
Current and future therapies for type 1 diabetes
Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
A little help from residual β cells has long-lasting clinical benefits