Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J
Cell Metab. 2016 Dec 28. pii: S1550-4131(16)30595-2. PMID: 28041957

Of Interest A structural blueprint for interleukin-21 signal modulation Screening and prevention of type 1 diabetes: Where are we? Loss of ZNF148 enhances insulin secretion in human pancreatic β cells Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification Not the second fiddle: α cell development, identity and function in health and diabetes Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways Identifying type 2 diabetes risk genes by β-cell CRISPR screening Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Deep Visual Proteomics defines single-cell identity and heterogeneity Modular design of synthetic receptors for programmed gene regulation in cell therapies Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8 New insights into β-cell failure, regeneration and replacement Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation Using the T Cell Receptor as a Biomarker in Type 1 Diabetes Pancreatic islets in bed with microvasculature-companions for life Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium α-cell Gq signaling is critical for maintaining euglycemia A human ESC line for efficient CRISPR editing of pluripotent stem cells The physiological role of β-cell heterogeneity in pancreatic islet function Mutations and variants of ONECUT1 in diabetes Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes SARS-CoV-2 infection of islet β cells: Evidence and implications Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Engineering islets from stem cells for advanced therapies of diabetes Generation of insulin-producing pancreatic β cells from multiple human stem cell lines Defining a cure for type 1 diabetes: a call to action Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes Immunotherapy: Building a bridge to a cure for type 1 diabetes Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
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