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Of Interest
A structural blueprint for interleukin-21 signal modulation
Screening and prevention of type 1 diabetes: Where are we?
Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Not the second fiddle: α cell development, identity and function in health and diabetes
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors
The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
Identifying type 2 diabetes risk genes by β-cell CRISPR screening
Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation
Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells
Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus
Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Deep Visual Proteomics defines single-cell identity and heterogeneity
Modular design of synthetic receptors for programmed gene regulation in cell therapies
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
New insights into β-cell failure, regeneration and replacement
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
Pancreatic islets in bed with microvasculature-companions for life
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
α-cell Gq signaling is critical for maintaining euglycemia
A human ESC line for efficient CRISPR editing of pluripotent stem cells
The physiological role of β-cell heterogeneity in pancreatic islet function
Mutations and variants of ONECUT1 in diabetes
Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells
Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
SARS-CoV-2 infection of islet β cells: Evidence and implications
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
Engineering islets from stem cells for advanced therapies of diabetes
Generation of insulin-producing pancreatic β cells from multiple human stem cell lines
Defining a cure for type 1 diabetes: a call to action
Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes
Immunotherapy: Building a bridge to a cure for type 1 diabetes
Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus