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Of Interest
Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature
Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes
Sox9 regulates alternative splicing and pancreatic beta cell function
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice
Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
Decrease in multiple complement proteins associated with development of islet autoimmunity and type 1 diabetes
PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress
Extensive elimination of acinar cells during normal postnatal pancreas growth
Diabetes Study of Children of Diverse Ethnicity and Race: Study design
Golden age of immunoengineering
Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon
Stem cell-derived islet therapy: is this the end of the beginning?
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
A structural blueprint for interleukin-21 signal modulation
Screening and prevention of type 1 diabetes: Where are we?
Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors
The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
Identifying type 2 diabetes risk genes by β-cell CRISPR screening
Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation
Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells
Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus
Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Deep Visual Proteomics defines single-cell identity and heterogeneity
Modular design of synthetic receptors for programmed gene regulation in cell therapies
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
New insights into β-cell failure, regeneration and replacement
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
Pancreatic islets in bed with microvasculature-companions for life
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
α-cell Gq signaling is critical for maintaining euglycemia
A human ESC line for efficient CRISPR editing of pluripotent stem cells
The physiological role of β-cell heterogeneity in pancreatic islet function