A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

Consortia: CMAI

Zanetti G, Legut M, Chen A, Fathi F, Suek N, Teteloshvili N, Li HW, Ding X, Traum D, Kaestner KH, Hoang RE, Bremer E, Sewell AK, Parent AV, Creusot RJ, Sykes M, Khosravi-Maharlooei M.
bioRxiv [Preprint]. 2026 Feb 20:2026.02.19.706929. doi: 10.64898/2026.02.19.706929. PMID:41756994

Pre-Prints PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments Redundant γc cytokines license IL-1-driven neutrophil inflammation through MEK/ERK convergence Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling A Scalable Design for Proximity-Inducing Molecules Optimizing Post-Transplantation Detection of Subcutaneously Transplanted Islets Using Dithizone Staining Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility Exploring Size Exclusion Chromatography Columns 20 and 35 nm Pore Size Effect for Isolation of Extracellular Vesicles Integrative Spatial Omics for Systems-Level Mapping of Pathological Niches Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients BETA CELL DYSFUNCTION OCCURS INDEPENDENTLY OF INSULITIS IN TYPE 1 DIABETES PATHOGENESIS Coxsackievirus B infection invokes unique cell-type specific responses in primary human pancreatic islets An integrated map of cell type-specific gene expression in pancreatic islets
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