Diabetes Research Institute, University of Miami

A postdoctoral associate position is available at the Diabetes Research Institute of the University of Miami. The main lines of research in the Beta Cell Regeneration Lab revolve around the development of regenerative strategies for type 1 diabetes, including stem cell differentiation into insulin-producing β-cells and islet regeneration. In particular, our current research is focused on the induction of human pancreatic ductal BMP-responsive progenitor cells, which we have identified and characterized by lineage tracing (Klein et al., Diabetes, 2015; Qadir et al.Cell Reports, 2018); single-cell RNAseq and transplantation of sorted populations (Qadir et al., PNAS, 2020); and organotypic culture (human pancreatic slices) techniques (Qadir et al.Nature Comms, 2020). Our seminal contribution to the development of the latter has enabled for the first time the real-time monitoring of β-cell regeneration in an in vitro setting that resembles the native organ. Applicants for the position should provide a brief statement of research interests, CV, and the names of three references to Dr. Juan Dominguez-Bendala.

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Joslin Diabetes Center, Harvard Medical School

The Joslin Diabetes Center, Harvard Medical School  has two Post-Doctoral Fellowship open positions in the Kulkarni Lab. Two positions are available immediately for a period of 3 years each. For both positions applications are invited from individuals with a PhD or MD or MD PhD degrees. 1) The first position is for training in exciting projects focused on Metabolism such as defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology including inter-organ cross-talk in the overall maintenance of glucose homeostasis. The projects will utilize including induced pluripotent stem cells, genetically engineered and humanized mouse models. Topics are flexible – some examples include growth factor (e.g. insulin/IGF-1) signaling, mRNA modifications and stem cell biology. Candidates should have a strong background in molecular biology, cell biology (stem/iPS cells) and biochemistry. It is an advantage if candidates have the ability to interrogate “omics” and sequencing datasets. Candidates should possess skills or be willing to learn handling human islets, in vivo animal studies, rodent islet isolation and immunostaining. 2) For the second position candidates with expertise in Bioinformatics will be especially relevant. Prospective candidates should have expertise in handling large ‘omics’ databases and be willing to work closely with other Fellows in the lab to assist in analyses of biological data from diverse projects. Candidates will also be encouraged to develop their own research interests. Applicants for both positions should provide a brief statement of research interests, CV, and the names of three references to  Dr. Kulkarni

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University of Miami, Miller School of Medicine

The Department of Medicine at the University of Miami, Miller School of Medicine, has an exciting opportunity for a full time Postdoctoral Associate. This Postdoctoral Associate position will support Dr. Joao Pedro Werneck with his investigations that focus on implementing in vivo tools to understand the thyroid gland physiology and how exercise impacts human pancreatic islets.  Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Joao Saar Werneck de Castro.

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The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope

The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope has a postdoctoral position available in the laboratory of Dr. Komatsu / Dr. Kandeel in the Department of Translational Research & Cellular Therapeutics. They are seeking a creative, experienced and highly collaborative postdoctoral associate with a strong interest in the translational research in Type 1 diabetes. The research goal for this position is to establish the extrahepatic islet transplantation strategy in animal models that can be translated into the clinical. Several projects are ongoing with highly productive collaborators including extramural engineers. By integrating our broad knowledge of islet physiology with engineering approaches, we seek to develop novel strategy of islet transplantation. These projects are led by the principal investigator with extensive clinical experience as translational researches. The selected candidate will take initiative in developing the new islet transplantation approaches using animal islet transplantation models. Candidates with clinical experience, beta cell biology and/or molecular biology, are particularly welcome to apply. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Hirotake Komatsu.

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University of Alberta, Canada

The MacDonald Lab at the University of Alberta in Edmonton, Canada is looking to fill two postdoctoral positions within one or more of the following areas: cell physiology, single-cell biology, cell imaging, electrophysiology, and computational biology. The positions will be held within the Department of Pharmacology and the Alberta Diabetes Institute (ADI), Canada’s largest stand-alone diabetes research centre.  Successful candidates will have access to extensive resources for research through the MacDonald Lab, the ADI, and the University of Alberta Faculty of Medicine and Dentistry. This includes core facilities for molecular biology and biochemistry, sequencing and single-cell work, live-cell imaging, animal services, and more. Please send your CV, cover letter, and contact information with 3 references to Dr. Patrick McDonald.

 

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Washington University School of Medicine

The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. The candidate should have experience in stem cell culture and familiarity with techniques common in cell biology labs, including qRT-PCR, flow cytometry, and immunocytochemistry.  Qualified candidates are encouraged to contact Dr. Jeffrey Millman with their CV and the names of three references.

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Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU)

The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively several projects including a multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The main research focuses of the Nakai lab are: (1) AAV vector biology – capsid assembly, genome packaging, and virus-host interactions in rodents and non-human primates; (2) AAV antigen-antibody interactions; (3) developing novel vectors by engineering of AAV capsids; and (4) preclinical studies of gene therapy for the treatment of various human diseases including type I diabetes. Please send a cover letter and C.V. to Dr. Hiroyuki Nakai.

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The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope

The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope is looking for a talented postdoctoral fellow. The collaborative laboratories of Drs. John Kaddis and Bart Roep are jointly seeking innovative postdoctoral candidates to conduct in-silico translational research in the field of type 1 diabetes (T1D). This individual will participate in one or more projects that examine the role of molecular, cellular, genetic, and epidemiological variation in T1D. This candidate will have an opportunity to work with specialists in the fields of immunology, diabetes, and data/computer science. Expertize in statistical methods for disease risk prediction and modeling, as well as clinical data, genome sequence, SNP array, “-omics”, and large-scale genetic association analysis is helpful. Experience with public databases/repositories is highly desired. Necessary skills include those from bioinformatics, computer/data science, mathematics, software engineering, and computational biology.  Interested applicants should send a letter, CV, and contact information for 2-4 references to Dr. John Kaddis.

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The University of California, San Francisco

The University of California, San Francisco, is looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging. We have identified key immune cells that can selectively eliminated senescent cells in a number of diseases associated with agingWe use a combination of mouse models of autoimmunity and humanized mouse models transplanted with senescent cells to investigate the underlying mechanism by which tissue senescent cells contribute to the development of the various diseases. We pay salaries that are more generous than traditional academic scales. The collegiality and interdepartmental organization at UCSF fosters interdisciplinary research that helps hone research skills, critical thinking, and scientific writing for a broad range of jobs.  Please send cover letter and CV/resume to Dr. Anil Bhushan.

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