Human Islet Research Network

Job Postings – Research

Faculty Positions

The Lilly Diabetes Center of Excellence (LDCE) at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D). You may obtain additional information by contacting Dr. Decio Eizirik.
Date Posted: November 6, 2019  Job Announcement (174 downloads)  

The Diabetes Center of Excellence at the University of Massachusetts Medical School invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The Diabetes Center of Excellence currently consists of basic and physician scientists representing a broad range of disciplines in the biomedical and clinical sciences, with members from several Medical School Departments and Programs working together as central New England’s leading center for diabetes clinical care, innovation, and discovery. The Center occupies state-of-the-art research space on an expanding Medical School campus. Basic investigators benefit from core facilities for deep sequencing, proteomics, genotyping, fluorescence-activated cell sorting, digital imaging/confocal microscopy, genomics/bioinformatics, transgenic/knockout mice, and mouse metabolic phenotyping. Clinical and community investigators benefit from infrastructure for recruitment and retention of research participants, measurement, behavioral and nutritional intervention resources and facilities, and academic-community research partnerships. Adult and pediatric clinical efforts of the Diabetes Center are housed in a wonderful Ambulatory Clinical Care building designed so that patients can receive appropriate retinal photos, foot care, diabetes education, and other routine medical care at one location. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment. Applicants should send curriculum vitae, statement of research interests, and names and addresses of three references to Drs. Harlan and Greiner  c/o Patricia Cannon.
Date Posted: August 27, 2019   Job Announcement (215 downloads)

The Diabetes Clinical Research Program (DCRP) at Benaroya Research Institute at Virginia Mason (BRI) seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement.  The DCRP is an international leader in type 1 (autoimmune) diabetes research.  We are looking for an investigator with strong interest in clinical research and clinical trials to take a leadership role within the DCRP and work on national, regional, and local projects in type 1 diabetes. The successful candidate will be expected to contribute to the overall DCRP through participation in ongoing programs and initiation of new projects. Experience in epidemiology, clinical investigation and/or clinical trials preferred; however, applicants with related research experience will be considered including work outside of type 1 diabetes.  Requires an MD and a license to practice medicine in US. Qualified candidates should send inquiries or an application package comprising their curriculum vitae, a letter explaining their motivation, research interests and qualifications to Benaroya research.
Date Posted: October 26, 2020  Job Announcement (23 downloads)  

The University of Miami Miller School of Medicine Department of of Microbiology and Immunology is accepting applications for Assistant and Associate Professor level for investigators with research interests related to immunotherapy of cancer, autoimmunity, or infectious diseases. We are particularly interested in applicants that study the human immune response and have an established funded research program. Significant resources will be made available toward this recruitment. Applicants should have a Ph.D., M.D. or equivalent, at least 3 years of postdoctoral training, and a willingness to contribute to the missions of the Department of Microbiology and lmmunology and the Miller School of Medicine. Quality research facilities, start-up funds, and salary support will be provided to the appointees. Applicants should send a curriculum vitae, statement describing research accomplishments and future research goals, relevant reprints, and the names of three references to Ms. Silvia Arguelles
Date Posted: December 12, 2018  Job Announcement (341 downloads)  

Research Scientist Position

The University of Washington Diabetes Research Center (DRC) Cell Function Analysis Core is recruiting a Research Scientist working to work on isolation of islets and other cell types using microsurgical and gradient purification techniques and cell culture; and investigating the function, bioenergetics and intracellular signaling in cells/islets from normal and diabetic models/patients using a variety of assays including sophisticated, real-time spectroscopic and imaging techniques.  In addition, effort will be spent on the development of instrumentation for cell analysis that involves the design, implementation, testing and optimization of optical sensors and microfluidics.   Opportunities will be available for writing and publishing manuscripts both on mechanisms mediating and regulating insulin secretion, as well as new optical and fluidic technologies. Please send a brief cover letter and resume (containing 2-3 references) to Dr. Ian Sweet.  
Date Posted: June 30, 2020  Job Announcement (66 downloads)

Postdoctoral Fellow Positions

The University of Florida under the Stabler laboratory is seeking a creative and dedicated postdoctoral associate to join our team in working on translational research in Type 1 diabetes. The research goals for this position are in the translation of our bioactive scaffolds and coatings into preclinical models for validation and optimization. As a highly collaborative laboratory, the Associate will integrate as a part of our team, working together with members of the laboratory, as well as our extensive researcher network. The Associate will be expected to take a leadership role in the laboratory, directing research goals and timelines, mentoring students, and writing reports and publications. Interested candidates should submit a CV, a summary of future research interests and goals, and three references to Dr. Cheri Stabler.  
Date Posted: January 15, 2021 Job Announcement (1 download)

Pacific Northwest National Laboratory (PNNL) is seeking an outstanding Post-Doctoral candidate to join our multi-disciplinary team focused on mass spectrometry (MS) based omics analyses. This project is part of the Human Islet Research Network funded by the National Institute of Health. We are investigating the roles of alternative splicing in beta cell stress and development of type 1 diabetes. The project focus on the identification and validation of alternative splicing products by global and targeted proteomics, respectively. The candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university. The ideal candidate would have a Ph.D. degree in Biochemistry, Endocrinology, Analytical Chemistry, Systems Biology, Physiology or related fields. Hands-on experience in LC-MS for proteomics analysis or in Endocrinology and human metabolism is preferred, but it is not required. You can obtain additional information HERE.
Date Posted: December 22, 2020 Job Announcement (1 download)

Diabetes Research at Washington University in St. Louis has a postdoctoral research associate position is available in the Hughes Lab, to study primary cilia in islet cells. The laboratory combines standard molecular and cell biology with advanced imaging techniques to explore novel roles of cilia in mouse and human islets. We have generated new cilia knockout mouse models with strong diabetic phenotypes and are looking for someone to lead the investigation of cilia mediated signaling mechanisms in islet hormone secretion. For human studies, we have a funded project to image primary cilia in T1D pancreas which will generate important and clinically relevant findings in autoimmune diabetes. Interested candidates please email Dr. Hughes.
Date Posted: December 22, 2020 Job Announcement (1 download) Diabetes Research Center has an open PhD Position.  The lab is focused on pancreatic beta-cell biology and its perturbations in type 2 diabetes.  The objective of this project is to explore the mechanisms whereby the pancreatic betacell increases its functional mass during puberty and their impact on glucose homeostasis in adulthood, using a combination of in vitro and in vivo approaches. The successful applicant will hold an MSc. degree in biochemistry, cell biology or physiology (or equivalent) and be eligible to the biochemistry, pharmacology or physiology programs at the University of Montreal. Application to training awards from funding agencies is strongly encouraged.  Please send a cover letter and curriculum vitae, including university transcripts and 2-3 names of potential references, to Dr. Vincent Poitout.
Date Posted: November 6, 2020 Job Announcement (21 downloads)

Postdoctoral position available at the Montreal Diabetes Research Center under the direction of Dr. Vincent Poitout.  Our laboratory is studying pancreatic beta-cell biology and its perturbations in type 2 diabetes. The objectives of project are to decipher the physiological role of the fatty-acid receptor FFAR4 (GPR120) in pancreatic islet hormone release and to identify its intracellular signaling mechanisms.  The successful applicant will hold a PhD or equivalent. Experience in islet biology and/or glucose homeostasis is required.  Please send a cover letter and curriculum vitae, including three references, to Dr. Vincent Poitout.
Date Posted: October 21, 2020  Job Announcement (26 downloads)

The University of Michigan has a fully-funded postdoctoral fellowship position available in the Soleimanpour islet mitochondria laboratory, where we are interested on the interface of mitochondria and the ER in the development of type 1 diabetes (T1D). We are seeking highly motivated candidates (who possess a Ph.D., M.D., or equivalent degree) interested in conducting research focused on understanding molecular and genetic causes of diabetes.  The fellow will be mentored in preparation of manuscripts, presentation of work at national/international meetings, and grant submissions to support their development of skills needed for the remainder of their career. Candidates with previous training in beta cell biology are particularly encouraged to apply.  Please send your CV, cover letter, and contact information with 3 references to Dr. Soleimanpour.
Date Posted: October 20, 2020  Job Announcement (24 downloads)

Applications are invited for a Postdoctoral Fellow in Functional Genomics position that spans the laboratories of Drs. Steve Parker and Jacob Kitzman in the Departments of Computational Medicine & Bioinformatics and Human Genetics at the University of Michigan Medical School. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the noncoding portion of the genome (from GWAS), with a focus on type 2 diabetes. We accomplish this through an interdisciplinary combination of molecular/cellular and computational methods. We generate multiple high-throughput functional genomics data sets on the genome, epigenome, and transcriptome across species and in disease-relevant tissues/cells and use computational approaches to integrate and analyze this data. The applicant will help organize and lead research projects involving molecular biology, cell biology, genomics, and genetics, which involves critical evaluation and presentation of scientific literature. The position will focus heavily on generation and analysis of high-throughput single-cell molecular profiles (ATAC-seq, RNA-seq, STARR-seq, and CUT&Tag) from bulk tissue and iPSC samples and on single-cell platforms.  Send a CV, cover letter describing your research experiences and ongoing research interests (including specific interest in this opportunity), and contact information for three references to Dr. Steve Parker and  Dr. Jacob Kitzman
Date Posted: October 20, 2020  Job Announcement (26 downloads)

The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. The candidate should have experience in stem cell culture and familiarity with techniques common in cell biology labs, including qRT-PCR, flow cytometry, and immunocytochemistry.  Qualified candidates are encouraged to contact Dr. Millman with their CV and the names of three references. 
Date Posted: October 20, 2020  Job Announcement (26 downloads)

Postdoctoral Scholar Positions available at the Hughes Lab, in the University of California, Irvine.  An NIH-funded postdoctoral position is available to work on the development of body-on-chip devices in the areas of pancreatic islets (Type 1 diabetes). The ideal candidate will have experience in cell culture, vascular biology, bioengineering (including COMSOL modeling), and microfluidic systems. Prior knowledge in the areas of diabetes would be an advantage, however, candidates with any combination of the above should consider applying. Qualified candidates should send curriculum vitae, a cover letter outlining research experience and interests, and the names, phone numbers and e-mail addresses of three references.  Apply here 
Date Posted: October 20, 2020  Job Announcement (26 downloads)

Rutgers, the State University of New Jersey, is seeking a Research Associate for the Child Health Institute of New Jersey. The position is available in El Ouaamari’s laboratory to investigate the role of the peripheral neurons in the regulation of systemic energy homeostasis in the context of obesity and diabetes. Self-driven, creative, resourceful and independent candidates with a PhD in neuroscience or neurobiology are encouraged to apply. Prior postdoctoral experience in neuroscience or related fields is required. Successful applicants will develop a research program focused on understanding how peripheral neurons control glucose and lipid homeostasis—with the long-term goal of identifying high-value biological data that can be harnessed to design neuromodulation-based strategies to counter obesity and diabetes. The candidate must be skilled in using in vitro and in vivo techniques for manipulating and monitoring neuronal activity and should have strong records of productivity and achievement. Preference will be given to applicants who have experience in diabetes research as well. Please send cover letter and CV to Dr. Abdelfattah El Ouaamari.
Date Posted: October 20, 2020  Job Announcement (26 downloads)

The Arrojo e Drigo lab at Vanderbilt University focuses on the mechanisms regulating post‐mitotic cell homeostasis and longevity. Many postmitotic cells can be as old as the organism, which makes them remarkably long‐lived. We study long‐lived cells in different organs and explore their developmental trajectory, structure‐function and aging patterns. Our lab uses a combination of single cell sequencing and high‐resolution light, electron and isotope microscopy platforms to overlay cell structure‐function with molecular identity, age and metabolism. Applications are invited for a postdoctoral position to study the physiology of long‐lived cells in the pancreas. The proposed research includes addressing questions such as how nutrient availability and metabolic disease (i.e. Type 1 or Type 2 Diabetes) impacts cell longevity, cell function and glucose homeostasis mechanisms.  To apply, please send a over letter, up to date CV, and names and contact information for three references to Dr. Rafael Arrojo e Drigo.
Date Posted: October 20, 2020 Job Announcement (26 downloads)

The Powers & Brissova research group in the Vanderbilt Diabetes Center is a seeking postdoctoral fellows to study human pancreas and islet biology with a focus on gene expression and developmental biology of single cells. We are especially interested individuals with computational or informatics expertise, multimodal, multiplex experience, or live cell imaging experience. Please send current CV to Dr. Al Powers.
Date Posted: October 20, 2020 Job Announcement (26 downloads)


The Voight lab invites applications for a computational Post-Doctoral position at the University of Pennsylvania School of Medicine, within the Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics. The lab focuses on translating discoveries from human genetics data into insights about the biological basis and genetic architecture of human disease (ultimately toward developing new therapeutics targets for human disease), and understanding selection during recent human evolution.  The candidate will have a MD, PhD, or equivalent doctorate, with a strong background in one or more of the following areas: statistics, biostatistics, population genetics, human genetics, genetic epidemiology, computational biology and/or genomics, bioinformatics.  To apply, please send (i) a cover letter that includes the names and contacts for three references and a short statement of research interests, and (ii) a current CV to: Dr. Benjamin Voight.
Date Posted: October 20, 2020 Job Announcement (25 downloads)

A Postdoctoral Research Associate is available at the Benaroya Research Institute under the direction of Dr. Alice Long.  The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy.  Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and 3) identification of biomarkers of disease severity.  The Postdoctoral Research Associate conducts independent biomedical research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of type 1 diabetes (T1D). The Postdoctoral Research Associate is a team-player who welcomes challenges and wants to grow as a translational biologist. Requires a Ph.D. in Immunology or a related field and experience in tissue culture, cellular and molecular techniques. Apply here.
Date Posted: October 16, 2020  Job Announcement (30 downloads)  

A postdoctoral researcher position studying human islet biology is available in the laboratory of Dr. Ed Phelps Lab in the University of Florida. The postdoctoral researcher will work on currently funded NIH projects: R01 TBD “Mechanism and dynamics of islet GABA signaling” and HIRN UG3 DK122638 02 “Engineering a human microphysiological system for the characterization of islet-immune interactions”.  A background in islet biology, neuroscience, or cell/molecular biology will beneficial to the success of the project. Applicants should send a CV, a brief statement of interest, and contact information for two references to Dr. Phelps
Date Posted: October 16, 2020  Job Announcement (33 downloads)

The University of Chicago beta cell/diabetes research group under the direction of Dr. Raghu Mirmira has funded openings for several postdoctoral research scientists with interest in applying/learning cell biological techniques (immunoprecipitation, immunohistochemistry, confocal imaging), mouse genetic skills, human islet biology, and immunology and inflammation research.  NIH-funded research projects in the Mirmira laboratory include the study of beta cell development and function, human islet gene regulation and mRNA translation, and islet cytokine signaling in the context of type 1 diabetes.  The University of Chicago Diabetes Center is a highly interactive and diverse research environment with a strong history of mentoring and career development of junior scientists.  In addition to a rich research environment, the Center and School of Medicine provide numerous scientific seminar series, career development workshops, and the opportunity to interact with a diverse pool of international scientists in a dynamic and exciting city.  Interested applicants are encouraged to send an updated CV and names of 3 references to Dr. Raghu Mirmira, MD, PhD, Director, Department of Medicine, University of Chicago
Date Posted: July 31, 2020 Job Announcement (26 downloads)

One postdoctoral fellow position available at the Indiana Biosciences Research Institute in the IBRI Diabetes Center. We are looking for highly motivated researchers to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens.The selected candidate will participate in a team working with primary human and rodent islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. A strong understanding of beta cell biology and/or molecular biology is important. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the lab. Applications can be made here. You may also contact Dr. Decio Eizirik directly for additional information. 
Date Posted: February 19, 2020  Job Announcement (106 downloads)  

Postdoctoral positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School.  Applications are invited for prospective Post-Doctoral Fellows to train in the Kulkarni Lab. The position is available immediately for a period of 2 years with the possibility of extending for a third year based on available funds and performance of the Fellow. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in exciting projects focused on defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis. Successful candidates should have a strong background in molecular biology, cell biology and biochemistry. It is strongly preferable to have prior experience in bioinformatics and the ability to interrogate “omics” and sequencing datasets. Prospective candidates should possess skills in handling human islets and undertake animal studies. It would be an advantage to be able to undertake rodent islet isolation, and perform immunostaining. Applicants should provide a brief statement of research interests, CV, and the names of three references to Angellica Meng
Date Posted: June 12, 2020

The Department of Pathology at the Children’s Hospital of Philadelphia is seeking a highly motivated individual for a postdoctoral position. Our laboratory focuses on using human embryonic stem cell and iPS cell models to study human pancreatic development and diabetes. The NIH funded position aims to use the human ES/iPS system to study monogenic forms of diabetes using genome engineered stem cell lines.  Applicants must have a PhD or MD degree in the biological or physical sciences. Prior laboratory experience in cell culture, basic molecular biology, and flow cytometry is preferred. The position is available Fall of 2020, with some flexibility for a later start date.  CV, letters of reference and cover letter can be emailed to Dr. Paul Gadue.  
Date Posted: June 12, 2020  Job Announcement (68 downloads)

The Department of Microbiology and Immunology at the University of Miami, Miller School of Medicine, has an exciting opportunity for a Postdoctoral Associate. We are seeking a highly motivated, ambitious, creative, and dynamic postdoctoral research fellow to join Dr. Serafini’s, NIH-funded, translational group for projects in immunology, targets discovery, and in vivo targeted delivery of therapeutics and imaging reagents. Our group is pioneering the use of RNA therapeutics for the in vivo genetic modulation of beta cells and tumor infiltrating myeloid cells. This allows an unprecedented opportunity not only to understand the beta cell biology in diabetes and myelopoiesis in cancer, but also for the development of new therapeutics for clinical use. The main project that the Postdoctoral Associate will be involved in is delivery of therapeutics to human beta cells using newly discovered RNA aptamers specific for human and mouse beta cells. Thus, the candidate must possess skills in molecular biology, sh-, sa-, and guide- RNA and proven experience in manipulating pancreatic islets and work with animal models. Ph.D. or other doctoral degree in molecular biology, endocrinology, immunology, or similar fields or M.D. Prefer proven experience in molecular biology and RNA. Good knowledge of aptamer technology and beta cell biology. Ability to successfully handle samples and perform immunology techniques and cell culture in a BSL2 setting. Must have a strong record of productivity and publication in the field of pancreatic islets and/or diabetes. Apply here.
Date Posted: May 18, 2020

The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The main research focuses of the Nakai lab are: (1) AAV vector biology – capsid assembly, genome packaging, and virus-host interactions in rodents and non-human primates; (2) AAV antigen-antibody interactions; (3) developing novel vectors by engineering of AAV capsids; and (4) preclinical studies of gene therapy for the treatment of various human diseases including type I diabetes. The lab takes a multidisciplinary approach to solving these problems, utilizing both wet and dry lab techniques. The lab is a part of the Human Islet Research Network (HIRN) supported by the NIH NIDDK. The successful candidate will join a multidisciplinary collaborative team and participate in global collaboration in the HIRN community, with an ultimate goal to develop AAV gene therapy for type I diabetes. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff. Please send a cover letter and C.V. to Hiroyuki Nakai, M.D., Ph.D
Date Posted: January 22, 2020  Job Announcement (97 downloads)

The Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity. Work includes use of animal models and human samples. Immunology, in vivo mouse models, and flow cytometry experience are preferred. The successful candidate will be expected to design and implement projects, work with both human samples and mice, collaborate within and between labs, participate in the drafting of scientific publications and funding proposals, and may, with direction from the PI, supervise technical support personnel. The selected individual will receive strong mentoring to promote scientific growth and development.  Candidates should submit a curriculum vitae, NIH Biosketch/personal research statement (one-two pages), and three letters of recommendation. The letters of reference should be sent directly to Prof. Todd Brusko
Date Posted: December 3, 2019

We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging. We have identified key immune cells that can selectively eliminated senescent cells in a number of diseases associated with aging. We use a combination of mouse models of autoimmunity and humanized mouse models transplanted with senescent cells to investigate the underlying mechanism by which tissue senescent cells contribute to the development of the various diseases. We pay salaries that are more generous than traditional academic scales. The collegiality and interdepartmental organization at UCSF fosters interdisciplinary research that helps hone research skills, critical thinking, and scientific writing for a broad range of jobs.  Please send cover letter and CV/resume to Dr. Anil Bhushan.  
Date Posted: October 25, 2019

Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the Beckman Research Institute at City of Hope, in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. The candidate should send a cover letter/statement of research interests, CV, and contact information for three references directly to Dr. Sangeeta Dhawan
Date Posted: February 8, 2019

Postdoctoral position in the Lab of Dr. Doris Stoffers in the Institute for Diabetes, Obesity, and Metabolism within the Perelman School of Medicine at the University of Pennsylvania. We are investigating molecular mechanisms whereby pancreatic beta cells respond to stress.  Failure of beta cell numbers or function underlies the progression of all forms of diabetes and we envision that our progress in this area could identify new nodes to target for therapeutic intervention.  Our current efforts are focused on a stress responsive Pdx1 containing transcriptional complex and its targets and on the role of the polyC binding protein family of RNA binding proteins in the post-transcriptional regulatory landscape of beta cells.  A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful. Please send a brief statement of research interests, CV and contact information for three references to Dr. Doris Stoffers
Date Posted: November 11, 2018

Postdoctoral position at University of Pennsylvania to be part of the Human Pancreas Analysis Program (HPAP).  The individual will contribute to our project on “Drivers and consequences of beta cell DNA damage in type 1 diabetes” within HIRN CBDS consortium.  We propose to develop novel technologies to determine physiological responses to genomic stress in human beta cells, including the potential accumulation of somatic mutations, all at the single cell level. We will analyze the cumulative mutation load of human beta-cells in diabetes, based on our hypothesis that metabolic insults and abortive replication attempts result in the accumulation of somatic mutations, contributing to loss of function and possibly to immunogenicity in diabetes. To accomplish this goal, we will determine the cumulative mutation load of stressed beta-cells using single cell exome-, RNA-, and ATACseq analysis. We will employ cutting-edge and emerging technologies that are already established in our laboratories. We have assembled an outstanding team of scientists with complementary expertise, ranging from human islet transplantation to computational biology, to assemble an atlas of the human endocrine pancreas in health and disease at the single cell level. The successful applicant will join a highly interactive and productive team, and will build on our existing technologies existing in the Kaestner Lab.  Ph.D. or equivalent are required, with expertise islet biology and molecular genetics. Send CV and two letters of recommendation directly to Dr. Klaus Kaestner.
Date Posted: August 21, 2018

Research Positions

The NIDDK Information Network (dkNet) has an open position for a Community Liaison to provide community outreach and lead engagement with the scientific community. This position will support a range of activities linked to community-dkNET partnerships, researcher engagement and knowledge networking. The position will entail engaging with research scientists, students and trainees, government, industry and broader audiences through workshops, in-person outreach events, multimedia, social media and Web-based systems. dkNET was launched by the FAIR Data Informatics Laboratory at the University of California, San Diego to serve the needs of basic and clinical investigators in diabetes, digestive and kidney disease by addressing the challenge of connecting researchers to research resources, assisting researchers with rigor and reproducibility guidelines, supporting researchers in navigating new data sharing requirements, and providing tools in enabling data discovery and hypothesis generation. More information HERE.
Date Posted: December 22, 2020 Job Announcement (1 download)

A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group University of British Columbia has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the dayto-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages.  Candidates should submit a cover letter outlining research interests and fit with the laboratory’s research along with resume.
Date Posted: October 20, 2020.  Job Announcement (30 downloads)

The laboratory of Dr. Vincent Poitout is seeking a PhD student interested in cell biology, signalling and glucose homeostasis. Requirements: MSc. degree in biochemistry, cell biology or physiology (or equivalent) and be eligible to the biochemistry, pharmacology or physiology programs at the Université de Montréal. Our laboratory is focusing on pancreatic beta-cell biology and its perturbations in type 2 diabetes ( The objective of this project is to explore the mechanisms whereby the pancreatic beta-cell increases its functional mass during puberty and their impact on glucose homeostasis in adulthood, using a combination of in vitro and in vivo approaches. The candidate will receive a scholarship according to the CIHR guidelines. Application to training awards from funding agencies is strongly encouraged. Interested students should send a motivation letter, a complete CV, university transcripts and 2-3 names of potential references to Dr. Vincent Poitout, before July 31, 2020. 
Date Posted: July 2, 2020 Job Announcement (53 downloads)