Job Postings – Research
Two postdoctoral fellow positions at the Indiana Biosciences Research Institute are available in the IBRI Diabetes Center. We are looking for highly motivated researchers to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens.The selected candidate will participate in a team working with primary human and rodent islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. A strong understanding of beta cell biology and/or molecular biology is important. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the lab. Applications can be made here. You may also contact Dr. Decio Eizirik.
Job Announcement (22 downloads)
Date Posted: February 19, 2020
A 3-year PhD research scientist position is available at the Institute of Physiology, Center for physiology and pharmacology, Medical University of Vienna. The candidate will work on an international joint research project called “Beta-cells in diet-induced diabetes and remission (Austrian Science Fund FWF project I3787-B21 and Slovene Research Agency project N3-0116). The project aims to validate a new western diet-induced model of obesity, metabolic syndrome and to precisely assess the mechanism and the organizational level of diet-induced beta cell injury and its reversibility in a mouse model. The fresh pancreas tissue slices will be used to perform electrophysiological and functional mutlicellular confocal imaging experiments. The beta cell collective activity will be assessed using tools of statistical physics.The candidate is expected to perform experimental work on both partner locations, Vienna and Maribor.Highly motivated students with a strong interest in physiology of pancreatic beta cells/computational biology are welcome to apply. Practical experience with electrophysiological techniques and computer coding (e.g. Python) will be considered as an advantage. The candidate should preferably hold a research-based master degree in neuroscience, biophysics or related disciplines and should be able to communicate in English at an advanced level. Candidate will receive a monthly salary according to the scales of the Austrian Science Fund FWF. Applications in English should be sent via a single PDF containing: CV, education certificates, one-page motivation letter and contact details of 3 senior scientist, who would be willing to give a reference. Only candidates selected for interviews will be contacted.
Job Announcement (13 downloads)
Date Posted: February 17, 2020
The Lilly Diabetes Center of Excellence (LDCE) at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D). You may obtain additional information by contacting Dr. Decio Eizirik.
Job Announcement (80 downloads)
Date Posted: November 6, 2019
The Diabetes Center of Excellence at the University of Massachusetts Medical School invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The Diabetes Center of Excellence currently consists of basic and physician scientists representing a broad range of disciplines in the biomedical and clinical sciences, with members from several Medical School Departments and Programs working together as central New England’s leading center for diabetes clinical care, innovation, and discovery. The Center occupies state-of-the-art research space on an expanding Medical School campus. Basic investigators benefit from core facilities for deep sequencing, proteomics, genotyping, fluorescence-activated cell sorting, digital imaging/confocal microscopy, genomics/bioinformatics, transgenic/knockout mice, and mouse metabolic phenotyping. Clinical and community investigators benefit from infrastructure for recruitment and retention of research participants, measurement, behavioral and nutritional intervention resources and facilities, and academic-community research partnerships. Adult and pediatric clinical efforts of the Diabetes Center are housed in a wonderful Ambulatory Clinical Care building designed so that patients can receive appropriate retinal photos, foot care, diabetes education, and other routine medical care at one location. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment. Applicants should send curriculum vitae, statement of research interests, and names and addresses of three references to Drs. Harlan and Greiner c/o Patricia Cannon.
Job Announcement (120 downloads)
Date Posted: August 27, 2019
The Diabetes Clinical Research Program (DCRP) at Benaroya Research Institute seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement. The DCRP is an international leader in type 1 (autoimmune) diabetes research. The program’s goal is to help families with type 1 diabetes by investigating ways to prevent the disease, finding new approaches of diagnosing it in its earliest stage to optimize the potential for successful treatment, and testing innovative new therapies.Benaroya Research Institute seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement. The DCRP is an international leader in type 1 (autoimmune) diabetes research. The program’s goal is to help families with type 1 diabetes by investigating ways to prevent the disease, finding new approaches of diagnosing it in its earliest stage to optimize the potential for successful treatment, and testing innovative new therapies. Qualified candidates should send inquiries or an application package comprising their curriculum vitae, a letter explaining their motivation, research interests and qualifications to Diabetes Recruit.
Job Announcement (103 downloads)
Date Posted: July 5, 2019
The University of Miami Miller School of Medicine Department of of Microbiology and Immunology is accepting applications for Assistant and Associate Professor level for investigators with research interests related to immunotherapy of cancer, autoimmunity, or infectious diseases. We are particularly interested in applicants that study the human immune response and have an established funded research program. Significant resources will be made available toward this recruitment. Applicants should have a Ph.D., M.D. or equivalent, at least 3 years of postdoctoral training, and a willingness to contribute to the missions of the Department of Microbiology and lmmunology and the Miller School of Medicine. Quality research facilities, start-up funds, and salary support will be provided to the appointees. Applicants should send a curriculum vitae, statement describing research accomplishments and future research goals, relevant reprints, and the names of three references to Ms. Silvia Arguelles.
Job Announcement (224 downloads)
Date Posted: December 12, 2018
Postdoctoral Fellow Positions
The laboratory of Dr. Seung Kim at the Stanford University School of Medicine and the Stanford Diabetes Research Center has an immediate opening for a post-doctoral fellow to work on one or more projects involving organ regeneration and development, stem cells, and diseases like diabetes mellitus. Our group has pioneered unique experimental approaches and integrative studies with primary human tissues, pigs, mice and fruit flies. We use classical methods and an array of modern assays including single cell and bulk RNA-Seq and ATAC-Seq, CLARITY, and CODEX. We are looking for self-motivated individuals willing to learn from a cheerful PI and our friendly team in the stimulating environments of the Stanford Department of Developmental Biology, the Stanford Diabetes Research Center and the JDRF Northern California Center of Excellence. Applicants with skills or interest in developmental biology, cell and stem cell biology, immunology, genetics, physiology and/or bioinformatics are especially encouraged to apply. Previous experience working with mice, mammalian cell culture, statistical and computational methods for analyzing genome-scale data sets or large imaging files is an asset, but not required. Prior experience with pancreas or islet biology, or diabetes research is not necessary. For those with a background in fruit fly genetics and an interest in developing a teaching-based career, there are special training opportunities with us. If interested, please send a cover letter, detailed CV, and names of three references directly to Ms. Ngan Tefera.
Date Posted: February 4, 2020
The Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity. Work includes use of animal models and human samples. Immunology, in vivo mouse models, and flow cytometry experience are preferred. The successful candidate will be expected to design and implement projects, work with both human samples and mice, collaborate within and between labs, participate in the drafting of scientific publications and funding proposals, and may, with direction from the PI, supervise technical support personnel. The selected individual will receive strong mentoring to promote scientific growth and development. Candidates should submit a curriculum vitae, NIH Biosketch/personal research statement (one-two pages), and three letters of recommendation. The letters of reference should be sent directly to Prof. Todd Brusko.
Date Posted: December 3, 2019
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The main research focuses of the Nakai lab are: (1) AAV vector biology – capsid assembly, genome packaging, and virus-host interactions in rodents and non-human primates; (2) AAV antigen-antibody interactions; (3) developing novel vectors by engineering of AAV capsids; and (4) preclinical studies of gene therapy for the treatment of various human diseases including type I diabetes. The lab takes a multidisciplinary approach to solving these problems, utilizing both wet and dry lab techniques. The lab is a part of the Human Islet Research Network (HIRN) supported by the NIH NIDDK. The successful candidate will join a multidisciplinary collaborative team and participate in global collaboration in the HIRN community, with an ultimate goal to develop AAV gene therapy for type I diabetes. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff. Please send a cover letter and C.V. to Hiroyuki Nakai, M.D., Ph.D.
Job Announcement (20 downloads)
Date Posted: January 22, 2020
We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging. We have identified key immune cells that can selectively eliminated senescent cells in a number of diseases associated with aging. We use a combination of mouse models of autoimmunity and humanized mouse models transplanted with senescent cells to investigate the underlying mechanism by which tissue senescent cells contribute to the development of the various diseases. We pay salaries that are more generous than traditional academic scales. The collegiality and interdepartmental organization at UCSF fosters interdisciplinary research that helps hone research skills, critical thinking, and scientific writing for a broad range of jobs. Please send cover letter and CV/resume to Dr. Anil Bhushan.
Date Posted: October 25, 2019
Postdoctoral position at Rutgers University/Robert Wood Johnson Medical School in the Lab of Dr. Abdelfattah El Ouaamari. Recruiting for a self-driven, creative and organized candidates with a PhD in neuroscience, biochemistry or molecular and cellular biology are encouraged to apply. The candidate must possess skills in manipulating and assessing neuronal activity. Prior experience working with rodents is required. Preference will be given to applicants who also have experience with pancreatic islets. Candidates should have a strong record of productivity and publication in the fields of neuroscience/neurobiology or islet biology. Interested individuals should send CV, cover letter and names and details of 3 references directly to Dr. El Ouaamari.
Job Announcement (184 downloads)
Date Posted: April 11, 2019
Postdoctoral positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School. Applications are invited for prospective Post-Doctoral Fellows to train in the Kulkarni Lab. The position is available immediately for a period of 2 years with the possibility of extending for a third year based on performance. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in the Kulkarni Lab on projects focused on defining pathways and mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis. Successful candidates should have a strong background in molecular biology, cell biology and biochemistry. It is strongly preferable to have prior experience in bioinformatics and the ability to interrogate “omics” and sequencing datasets; and possess skills in rodent islet isolation, handling and culture of rodent and human islets and metabolic tissues such as liver and adipose and immunostaining. Applicants should provide a brief statement of research interests, CV, and the names of three references to Trang Leonard .
Date Posted: March 18, 2019
Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the Beckman Research Institute at City of Hope, in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. The candidate should send a cover letter/statement of research interests, CV, and contact information for three references directly to Dr. Sangeeta Dhawan
Date Posted: February 8, 2019
Postdoctoral position in the Lab of Dr. Doris Stoffers in the Institute for Diabetes, Obesity, and Metabolism within the Perelman School of Medicine at the University of Pennsylvania. We are investigating molecular mechanisms whereby pancreatic beta cells respond to stress. Failure of beta cell numbers or function underlies the progression of all forms of diabetes and we envision that our progress in this area could identify new nodes to target for therapeutic intervention. Our current efforts are focused on a stress responsive Pdx1 containing transcriptional complex and its targets and on the role of the polyC binding protein family of RNA binding proteins in the post-transcriptional regulatory landscape of beta cells. A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful. Please send a brief statement of research interests, CV and contact information for three references to Dr. Doris Stoffers
Date Posted: November 11, 2018
Postdoctoral position at University of Pennsylvania to be part of the Human Pancreas Analysis Program (HPAP). The individual will contribute to our project on “Drivers and consequences of beta cell DNA damage in type 1 diabetes” within HIRN CBDS consortium. We propose to develop novel technologies to determine physiological responses to genomic stress in human beta cells, including the potential accumulation of somatic mutations, all at the single cell level. We will analyze the cumulative mutation load of human beta-cells in diabetes, based on our hypothesis that metabolic insults and abortive replication attempts result in the accumulation of somatic mutations, contributing to loss of function and possibly to immunogenicity in diabetes. To accomplish this goal, we will determine the cumulative mutation load of stressed beta-cells using single cell exome-, RNA-, and ATACseq analysis. We will employ cutting-edge and emerging technologies that are already established in our laboratories. We have assembled an outstanding team of scientists with complementary expertise, ranging from human islet transplantation to computational biology, to assemble an atlas of the human endocrine pancreas in health and disease at the single cell level. The successful applicant will join a highly interactive and productive team, and will build on our existing technologies existing in the Kaestner Lab. Ph.D. or equivalent are required, with expertise islet biology and molecular genetics. Send CV and two letters of recommendation directly to Dr. Klaus Kaestner.
Date Posted: August 21, 2018
One Laboratory Assistant position at the Indiana Biosciences Research Institute is available in the IBRI Diabetes Center. We are looking for highly motivated laboratory assistant to join the IBRI in the iPSC Core Facility coordinated by Dr. Decio Eizirik. This Core aims to differentiate pancreatic beta cells and other cell types departing from iPSC cells.The selected candidate will participate in a team working with iPSC derived beta cells, functional studies and advanced molecular biology techniques. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr Eizirik and other colleagues in the iPSC Core. Applications can be made here. You may also contact Dr. Decio Eizirik.
Job Announcement (13 downloads)
Date Posted: February 19, 2020