2017 Investigator Meeting: Poster PDFs
The 3rd Annual HIRN Investigator Meeting was held March 7 – 10, 2017 at the Hyatt Regency Hotel in Bethesda, MD.
Below is a listing of all of the Posters presented during the HIRN 2017 Poster Sessions. The Poster Session Summary contains a detailed summary of the posters presented including presenter, title, and affiliation (Consortium/PI).
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2 Stimulating β-cell Proliferation Through Targeted Demethylation of the Imprinting Control Region 2 on Chromosome 11p15
3 Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
4 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) does not Regulate Insulin in Mouse Islets and its Mutation
in Human Cystic Fibrosis (CF) Leads to Pancreatic Remodeling and Inflammation with Activation of Immune sSignaling within the Islet
5 Transcriptome data from 120 Individual Islets Reveal Heterogeneity Between Histologically Defined Phenotypes
6 Pax6 Maintains Pancreatic Beta Cell Identity by Activating Beta Cell Genes and Repressing Alternative Islet Cell Genes
9 α-Cell Induction of Polyhormonal Precursors in a Biomimetic Islet Capsule
11 Diabetic β-cell Dysfunction as a Failure of Adaptive Chromatin Remodeling
15 Type 1 Diabetes Beta Cells Derived from Nuclear Transfer ES Cells Protect Mice from Diabetes
16 Single Cell Analysis of Human Islets in Type I Diabetes (T1D) Using Highly Multiplexed Imaging
17 Investigating the Natural History of Type 1 Diabetes by Imaging Mass Cytometry
18 High-Resolution Imaging of Mouse Pancreatic Islets Using Constant-Distance Mode Nanospray
Desorption Electrospray Ionization Mass Spectrometry
20 Decreased Insulin Secretion and Impaired β-cell Autophagy Follows Loss of Secretory Pathway Ca2+ ATPase (SPCA1)
22 Genetic Manipulation of Type 1 Diabetes Candidate Risk Genes in Antigen-specific T Cells
24 Transcriptional Targeting of Human Alpha and Beta Cells Using Recombinant AAV
25 Modeling MODY3 with Human Pluripotent Stem Cells
26 A Novel Inter-organ Signaling Pathway Regulating Islet Insulin Secretion
27 Rapamycin Impairs β cell Function in Adult and Inhibits β cell Proliferation in Juvenile Human Islets in vivo
28 12-Lipoxygenase as a Novel Pathway Leading to Islet Beta Cell Functional Loss in Type 1 Diabetes
32 Islet Autoantibodies Are Associated with Insulitis but Not Beta Cell Loss in Type 1 Diabetes
33 Global Profile of Insulin and Islet Endocrine Cell Dynamics Throughout the Spectrum of b-cell Deficit
37 C-like Ig Domain of VTCN1 (B7-H4) is a Powerful Activator of Naïve T Cells to Functional Treg Conversion
39 Fluctuation Localization Imaging-based Fluorescence in situ Hybridization (FISH) for Counting RNA Copies in Single Islet Cells
40 A Metabolomics and GSIR Study to Investigate the Effects of Inflammation, Hypoxia, and High Glucose
on Human Pancreatic Islets and Their Function
41 Transcriptional Profiling of Alpha and Beta Cells in Donors with Type 1 Diabetes and Controls
42 Next Generation Humanized Mice Enables Studies of Human Innate Immunity and Diabetes in Response to Coxsackie B (CVB) Infection
43 Analysis of Pancreas and Islets of a 33-year-old male with 16 years of Clinical Type 1 Diabetes Reveals MODY3/HNF1A Diabetes
44 Circulating Preproinsulin (PPI) mRNA As a Potential Biomarker of β Cell Stress
47 Differential Endocrine and Exocrine Lipid and Protein Distributions in Wild-type and ob/ob Mice as Revealed by Tissue
Imaging Mass Spectrometry
48 Towards Beta Cell-Specific Serum Protein Biomarkers for Predicting T1D Development
49 Generation of Nature β-cells from Human Pluripotent Stem Cells in vitro
50 Quantitative Models of Insulin Release: Parallel GSIR Perfusion Studies of Free and Encapsulated Human and Murine Pancreatic Islets
52 Hpx1 Antibody Labels Multipotent Pancreatic Progenitors During Human Pancreas Development and Embryonic Stem Cell Differentiation
53 dkNET
54 Combining Gene Editing and Human Stem Cells to Study Diabetes
55 Teratomas are Common and May Inhibit Allogeneic Rejection Following Transplantation of Pancreatic Beta Cell Progenitors Generated
from Induced Pluripotent Stem Cells
56 β Cells that Resist Immunological Attack Develop During Progression of Autoimmune Diabetes in NOD mice
57 Nanoscale Proteomics Profiling of Laser Capture Microdissected Human Islets Revealed Novel Proteome Changes
of the Islet Cells at the Pre-T1D Stage
58 Cytokines Modulate Phosphorylation of Proteins Involved in Human β-cell Growth and Survival
61 T1D Exchange Overview
62 Development of Humanized Mouse Models to Study Interactions Between Human Immune Systems and Human Islets
63 Integrative Genomic Analysis of Human Insulinomas Combined with Synthetic Modified mRNA as a Platform to Generate
and Screen Beta Cell Mitogenic Candidates
64 Enhancing β-Cell Differentiation from Pancreatic Progenitors with the Disque Platform
66 Efficient Generation of Pancreatic Beta Cells from Gene Editing Compatible Human Pluripotent Stem Cells
68 Proteomic Analysis of Extracellular Matrix Composition of Human Islets of Langerhans
69 Structure-function Relationship in Long-term Cultured Human Islets
70 The Best AAV Transducer of Human Pancreatic Islets in vitro has a Strong Preference for Alpha Cells
71 Development of Liver-detargeting AAV Mutants Important for in vivo Islet Transduction by Comprehensive Alanine Scanning
of Multiple AAV Serotype Capsids
72 The IL15Rα Exon 6 Transmembrane Domain is not Required for the Development of NK Cells in NOD-SCID Mice
73 Functional Adult Bone Marrow HSCs Appear to Expand in the Bone Marrow of Transplanted Mice
74 Coxsackievirus Induced Proteomic Alterations in Cultured Primary Human Islets and EndoC-βH1 Cells
75 Proteomic Analysis of Disease Stratified Laser Captured Microdissected Human Islets
76 Co-expression Gene Networks in Islets of Langerhans Suggests Potential Interconnections Between Different Molecular Pathologies
77 Understanding Cell Interactions that Promote Beta Cell Function and Maintenance
78 iPSC derived pancreatic β-cells and Primary Islets Respond Similarly to Autoimmune Effector Mechanisms
79 hnRNPK Regulates the Translation of Stress-responsive Genes in Pancreatic Beta Cells
80 Augmented Islet Neogenesis during Pregnancy in a Mouse Model of Insulin Resistance
81 Human Insulinoma Data Mining Reveals Broad Epigenetic Dysfunction Among Human Insulinomas and Novel Mechanisms and
Targets for Therapeutic Induction of Human Beta Cell Regeneration
84 PTPN22 Regulates p38 MAPK Phosphorylation and Downstream Production of T cell Skewing Cytokines in Dendritic Cells
86 Single-cell Analyses of the Endocrine Pancreas from an 18-day Old Donor
87 IIDP Overview
88 iPSC Working Group Overview
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