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Dimensions of Immunologic Memory
Homann D
, Kedl RM.
Immunol Rev. 2018 May;283(1):5-6. PMID: 29664575
Of Interest
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes
Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways
Synthetic organizer cells guide development via spatial and biochemical instructions
Time to reframe the disease staging system for type 1 diabetes
Advances in basic biology and translation in islet research
Revisiting the Pattern of Loss of β-Cell Function in Preclinical Type 1 Diabetes
Unveiling islet heterogeneity using an automated microfluidic imaging system
Droplet-based fluorescence anisotropy insulin immunoassay
Safeguarding genomic integrity in beta-cells: implications for beta-cell differentiation, growth, and dysfunction
Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes
The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation
Rebalancing the Immune System to Treat Type 1 Diabetes
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes
Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas
Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
Serum from pregnant donors induces human beta cell proliferation
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
Harnessing regulatory T cells to establish immune tolerance
Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature
Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes
Sox9 regulates alternative splicing and pancreatic beta cell function
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice
Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
Decrease in multiple complement proteins associated with development of islet autoimmunity and type 1 diabetes
PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress
Extensive elimination of acinar cells during normal postnatal pancreas growth
Diabetes Study of Children of Diverse Ethnicity and Race: Study design
Golden age of immunoengineering
Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon
Stem cell-derived islet therapy: is this the end of the beginning?
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
A structural blueprint for interleukin-21 signal modulation
Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors
The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
Identifying type 2 diabetes risk genes by β-cell CRISPR screening
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