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Consortia: HIREC

PubMed ID: 123ABC

September 9, 2025 – LR Testing

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

Why do we use it?

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

 

Where does it come from?

Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of “de Finibus Bonorum et Malorum” (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, “Lorem ipsum dolor sit amet..”, comes from a line in section 1.10.32.

 

Of Interest Test Human Stem Cell-Derived β-cells Expressing An Optimized CD155 Reduce Cytotoxic Immune Cell Function for Application in Type 1 Diabetes Disease diagnostics using machine learning of B cell and T cell receptor sequences Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways Synthetic organizer cells guide development via spatial and biochemical instructions Time to reframe the disease staging system for type 1 diabetes Advances in basic biology and translation in islet research Revisiting the Pattern of Loss of β-Cell Function in Preclinical Type 1 Diabetes Unveiling islet heterogeneity using an automated microfluidic imaging system Droplet-based fluorescence anisotropy insulin immunoassay Safeguarding genomic integrity in beta-cells: implications for beta-cell differentiation, growth, and dysfunction Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation Rebalancing the Immune System to Treat Type 1 Diabetes Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice Serum from pregnant donors induces human beta cell proliferation Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production Harnessing regulatory T cells to establish immune tolerance Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes Sox9 regulates alternative splicing and pancreatic beta cell function Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis Decrease in multiple complement proteins associated with development of islet autoimmunity and type 1 diabetes PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress Extensive elimination of acinar cells during normal postnatal pancreas growth Diabetes Study of Children of Diverse Ethnicity and Race: Study design Golden age of immunoengineering Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon Stem cell-derived islet therapy: is this the end of the beginning? Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas A structural blueprint for interleukin-21 signal modulation Loss of ZNF148 enhances insulin secretion in human pancreatic β cells Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
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Email: hirnec@coh.org