Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes

Consortia: CBDS

Yi X, Martin-Vazquez E, Jawurek S, Zimath PL, Oliveira JG, Costa-Junior JM, Ilegems E, Wesley JD, Title AC, Yesildag B, Eizirik DL.
bioRxiv [Preprint]. 2025 Jul 31:2025.07.26.666935. doi: 10.1101/2025.07.26.666935. PMID:40766651

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Research Network (HIRN) Initiative Advances in Cell Replacement Therapies for Diabetes Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes Bend It Like Occam: Ductal Origin of New Islet Cells in Human Pancreas After Injury DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay The epigenetic landscape of fate decisions in T cells
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