Dnmt1 activity is dispensable in δ-cells but is essential for α-cell homeostasis
Damond N, Thorel F, Kim SK, Herrera PL.
Int J Biochem Cell Biol. 2017 Jan 21. pii: S1357-2725(17)30017-1. doi: 10.1016/j.biocel.2017.01.008. [Epub ahead of print] PMID: 28119131

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In’t Veld PA.
Diabetologia. 2017 Jan 9. doi: 10.1007/s00125-016-4195-x. [Epub ahead of print] No abstract available. PMID: 28070616

PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Swisa A, Avrahami D, Eden N, Zhang J, Feleke E, Dahan T, Cohen-Tayar Y, Stolovich-Rain M, Kaestner KH, Glaser B, Ashery-Padan R, Dor Y.
J Clin Invest. 2016 Dec 12. pii: 88015. doi: 10.1172/JCI88015. [Epub ahead of print] PMID: 27941241

Epigenetic control of β-cell function and failure
Bernstein D, Golson ML, Kaestner KH.
Diabetes Res Clin Pract 2016 Nov 21;123:24-36. doi: 10.1016/j.diabres.2016.11.009. Review.PMID: 27918975

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop
Jing G, Chen J, Xu G, Shalev A.
Molecular Metabolism. 2016 December 5; 12: 1208-1215.

CTAR 

Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets
Zhang J, Kaestner KH.
Methods Mol Biol. 2017;1507:95-111. PMID: 27832535

 CBDS, CMAI, CTAR

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.
Nat Med 2016 Oct 31. doi: 10.1038/nm.4203.

 CTAR

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.
Cell Metab. 2016 Oct 11;24(4):616-626. doi: 10.1016/j.cmet.2016.09.007. PMID: 27732837

CTAR

Keeping tabs on fructose.
Shalev A.
Elife. 2016 Oct 11;5. pii: e21263. doi: 10.7554/eLife.21263. PMID: 27725088

CTAR 

Single-Cell Transcriptomics of the Human Endocrine Pancreas

Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML, Kaestner KH.
Diabetes. 2016 Oct;65(10):3028-38. doi: 10.2337/db16-0405. Epub 2016 Jun 30. PMID: 27364731

CTAR

Development of a reliable, automated screening system to identify small molecules and biologics that promote human β cell regeneration.
Aamodt KI, Aramandla R, Brown J, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC.
Am J Physiol Endocrinol Metab. 2016 Sep 13:ajpendo.00515.2015. doi: 10.1152/ajpendo.00515.2015.  PMID: 27624103

CMAI, CTAR

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC.
J Clin Invest. 2016 May 2;126(5):1857-70. doi: 10.1172/JCI83657. Epub 2016 Apr 11.  PMID: 27064285

 CTAR

G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O’Brien RM.
Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.  PMID: 27300767

 CTAR

Stress-induced adaptive islet cell identity changes. Cigliola V, Thorel F, Chera S, Herrera PL.
Diabetes Obes Metab. 2016 Sep;18 Suppl 1:87-96. doi: 10.1111/dom.12726. Review. PMID: 27615136

CTAR 

Effects of ageing and senescence on pancreatic β-cell function.
Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, Dor Y.
Diabetes Obes Metab. 2016 Sep;18 Suppl 1:58-62. doi: 10.1111/dom.12719. Review PMID: 27615132

CMAI, CTAR

End Sequence Analysis ToolKit (ESAT) expands the extractable from single cell RNA-seq experiments

Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov M, Garber M.

Genome Res. 2016 Jul 28. pii: gr.207902.116. PMID: 27470110

 CTAR

Human islets contain four distinct subtypes of β cells.
Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M.
Nat Commun. 2016 Jul 11;7:11756. doi: 10.1038/ncomms11756. PMID: 27399229

CTAR 

MiR-204 targets PERK and regulates UPR signaling and beta cell apoptosis.
Xu G, Chen J, Jing G, Grayson TB, Shalev A.
Mol Endocrinol. 2016 Jul 6:me20161056. PMID: 27384111

CTAR

Regeneration of pancreatic insulin-producing cells by in situ adapative cell conversion
Chera S, Herrera PL.
Curr Opin Genet Div. 2016 June 3; 40: 1 – 10. doi: 10.1016/j.gde.2016.05.010

CTAR

Replicative capacity of β-cells and type 1 diabetes
Saunders D, Powers AC.
J Autoimmun. 2016 Apr 28. pii: S0896-8411(16)30027-0. doi: 10.1016/j.jaut.2016.03.014. Review. PMID: 27133598

CTAR

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.
Cell Metab. 2016 Apr 27. pii: S1550-4131(16)30122-X. doi: 10.1016/j.cmet.2016.04.002. PMID: 27133132

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist
Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.
eLIFE. http://dx.doi.org/10.7554/eLife.13828 

 CBDS, CTAR

The genetic program of pancreatic beta-cell replication in vivo.
Klochendler A, Caspi I, Corem N, Moran M, Friedlich O, Elgavish S, Nevo Y, Helman A, Glaser B, Eden A, Itzkovitz S, Dor Y.
Diabetes. 2016 Mar 18. pii: db160003. PMID: 26993067 

CBDS, CTAR 

Identification of tissue-specific cell death using methylation patterns of circulating DNA
Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y.
Proc Natl Acad Sci U S A. 2016 Mar 14. pii: 201519286. PMID: 26976580

 CBDS, CTAR

p16^Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I.
Nat Med. 2016 Mar 7. doi: 10.1038/nm.4054. PMID: 26950362

CTAR

Stem cells versus plasticity in liver and pancreas regeneration
Kopp JL, Grompe M, Sander M.
Nat Cell Biol. 2016 Feb 25;18(3):238-45. doi: 10.1038/ncb3309. Review. PMID: 26911907 

CMAI, CTAR 

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K.
 Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.  PMID: 26912858

 CTAR

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes 
A. Ackerman, Z. Wang, J. Schug, A Naji, K. Kaestner. 
Mol Metab. March 2016; 5: 233-244

 CTAR

Cytokines Regulate β-Cell TXNIP via Distinct Mechanisms and Pathways
Hong K, Xu G, Grayson TB, Shalev A.
J Biol Chem. 2016 Feb 8. pii: jbc.M115.698365

 CTAR

Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes
Nakayama M, Simmons KM, Michels AW.
Curr Diab Rep. 2015 Dec;15(12):113. doi: 10.1007/s11892-015-0689-z. PMID:26458384

 CTAR

Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells
Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV.
Development. 2015 Nov 1;142(21):3637-48. doi: 10.1242/dev.126011. PMID: 26534984

 CTAR

Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish
Li M, Dean ED, Zhao L, Nicholson WE, Powers AC, Chen W.
J Endocrinol. 2015 Nov; 227(2):93-103. doi: 10.1530/JOE-15-0284. PMID: 26446275

 CTAR

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
Chen H, Kleinberger JW, Takane KK, Salim F, Fiaschi-Taesch N, Pappas K, Parsons R, Jiang J, Zhang Y, Liu H, Wang P, Bender AS, Frank SJ, Stewart AF
Diabetes. 2015 Nov; 64(11):3784-97. doi: 10.2337/db15-0083. Epub 2015 Jul 9. PMID: 26159175

CTAR 

β-Cell MicroRNAs: Small but Powerful
Filios SR, Shalev A. 
Diabetes. 2015 Nov; 64(11):3631-44. doi: 10.2337/db15-0831. PMID:26494215.  

CTAR 

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
Avrahami D, Li C, Zhang J, Schug J, Avrahami R, Rao S, Stadler MB, Burger L, Schübeler D, Glaser B, Kaestner KH.
Cell Metab. 2015 Oct 6;22(4):619-32. doi: 10.1016/j.cmet.2015.07.025. Epub 2015 Aug 27. PMID: 26321660 

 CTAR

The BisPCR(2) method for targeted bisulfite sequencing
Bernstein DL, Kameswaran V, Le Lay JE, Sheaffer KL, Kaestner KH.
Epigenetics Chromatin. 2015 Aug 1;8:27. doi: 10.1186/s13072-015-0020-x. eCollection 2015.  PMID: 26236400 

Human β-cell proliferation and intracellular signaling: part 3.
Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN.
Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Review. PMID: 25999530

 CBDS, CTAR

Current concepts on the pathogenesis of type 1 diabetes–considerations for attempts to prevent and reverse the disease
Atkinson MA, von Herrath M, Powers AC, Clare-Salzler M.
Diabetes Care. 2015 Jun;38(6):979-88. doi: 10.2337/dc15-0144.   PMID: 25998290

CTAR 

TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts
Bernstein DL, Le Lay JE, Ruano EG, Kaestner KH.
J Clin Invest. 2015 May;125(5):1998-2006. doi: 10.1172/JCI77321. Epub 2015 Apr 13. PMID: 25866970 

CTAR 

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles
Kayton NS, Poffenberger G, Henske J, Dai C, Thompson C, Aramandla R, Shostak A, Nicholson W, Brissova M, Bush WS, Powers AC.
Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E592-602. doi: 10.1152/ajpendo.00437.2014. Epub 2015 Feb 3.  PMID: 25648831