Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction

Kuo T, Damle M, González BJ, Egli D, Lazar MA, Accili D.
JCI Insight. 2019 May 23;5. pii: 128351. doi: 10.1172/jci.insight.128351. PMID:31120862

Of Interest α-cell Gq signaling is critical for maintaining euglycemia The physiological role of β-cell heterogeneity in pancreatic islet function Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes SARS-CoV-2 infection of islet β cells: Evidence and implications Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Engineering islets from stem cells for advanced therapies of diabetes Generation of insulin-producing pancreatic β cells from multiple human stem cell lines Defining a cure for type 1 diabetes: a call to action Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes Immunotherapy: Building a bridge to a cure for type 1 diabetes Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print Uncovering Pathways to Personalized Therapies in Type 1 Diabetes T cell circuits that sense antigen density with an ultrasensitive threshold HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing T cells selectively filter oscillatory signals on the minutes timescale Comprehensive analysis of single cell ATAC-seq data with SnapATAC The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes Current and future therapies for type 1 diabetes Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion A little help from residual β cells has long-lasting clinical benefits PDX1(LOW) MAFA(LOW) β-cells contribute to islet function and insulin release Inceptor counteracts insulin signalling in β-cells to control glycaemia Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size Exocrine Pancreas Dysfunction in Type 1 Diabetes Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?) There Is Something About Insulin Granules Precise T cell recognition programs designed by transcriptionally linking multiple receptors Evolution of insulin at the edge of foldability and its medical implications Islet vascularization is regulated by primary endothelial cilia via VEGF-A dependent signaling Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM Single nucleus and in situ RNA sequencing reveals cell topographies in the human pancreas Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes A high-stringency blueprint of the human proteome Engineering synthetic morphogen systems that can program multicellular patterning Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes? Covid-19 and Diabetes: A Complex Bidirectional Relationship Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes
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