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Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Consortia:
CBDS, HPAC
Chen CW
,
Guan BJ
,
Alzahrani MR,
Gao Z
,
Gao L
,
Bracey S
,
Haataja L
,
Schaffer AE
,
Lee H
,
Laframboise T
,
Bederman I
,
Arvan P
,
Mathews CE
,
Gerling IC
,
Kaestner
KH
,
Tirosh
B,
Engin
F,
Hatzoglou M
.
doi:
10.1101/2021.05.24.445193
All
Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors
Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry
Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque
Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis
Small-molecule discovery in the pancreatic beta cell
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis
Generation of human islet cell type-specific identity genesets
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival
Citrullination of glucokinase is linked to autoimmune diabetes
Rational Design of Silicon-Based Zinc Ionophores
RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells
Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells
Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations
Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo
Emerging Diabetes Therapies: Bringing back the β-cells
Stripenn detects architectural stripes from chromatin conformation data using computer vision
Development of a beta cell-specific expression control element for rAAV
Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes
Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes
Limited extent and consequences of pancreatic SARS-CoV-2 infection
Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
GDF15: a potential therapeutic target for type 1 diabetes
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
From the dish to humans: A stem cell recipe for success
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
3-D printed microfluidics for rapid prototyping and testing of electrochemical, aptamer-based sensor devices under flow conditions
Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury
Transgenic Drosophila lines for LexA-dependent gene and growth regulation
Cryopreservation and post-thaw characterization of dissociated human islet cells
Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress
Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections
Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development
Improving the Prediction of Type 1 Diabetes Across Ancestries
HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants
Robust differentiation of human enteroendocrine cells from intestinal stem cells
Cell maturation: Hallmarks, triggers, and manipulation
The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine
A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction
IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function
Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes
The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes
Modeling human T1D-associated autoimmune processes
Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes
Remote immune processes revealed by immune-derived circulating cell-free DNA
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies
CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles’ Heel?
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