Search Results for: ‘Patrick MacDonald’
Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes
…Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. bioRxiv. 2023 Jan 2:2022.12.31.522386. doi: 10.1101/2022.12.31.522386. PMID:36711922…
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
Consortia: CTAR Alghamdi TA, Krentz NAJ, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald…
Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes
…J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. Nat Genet. 2023 May 25. doi: 10.1038/s41588-023-01397-9. PMID:37231096…
HNF1α maintains pancreatic α and β cell functions in primary human islets
Consortia: CTAR Qian MF, Bevacqua RJ, Coykendall VM, Liu X, Zhao W, Chang CA, Gu X, Dai XQ, MacDonald PE, Kim SK. JCI Insight. 2023 Nov 9:e170884. doi: 10.1172/jci.insight.170884. PMID:37943614…
RFX6 maintains gene expression and function of adult human islet α cells
Consortia: CTAR, HPAC Coykendall VMN, Qian MF, Tellez K, Bautista A, Bevacqua RJ, Gu X, Hang Y, Neukam M, Zhao W, Chang C, MacDonald PE, Kim SK. Diabetes. 2023 Dec…
Modulation of insulin secretion by RBFOX2-mediated alternative splicing
Consortia: CBDS Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Nat Commun. 2023 Nov 25;14(1):7732. doi: 10.1038/s41467-023-43605-4. PMID:38007492…
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms
Consortia: CBDS Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer…
Cryopreservation and post-thaw characterization of dissociated human islet cells
Consortia: HPAC Marquez-Curtis LA, Dai XQ, Hang Y, Lam JY, Lyon J, Manning Fox JE, McGann LE, MacDonald PE, Kim SK, Elliott JAW. PLoS One. 2022 Jan 26;17(1):e0263005. doi: 10.1371/journal.pone.0263005….
HumanIslets: An integrated platform for human islet data access and analysis
…Consortium; Atlas E, Bruin JE, Mulvihill EE, Verchere CB, Foster LJ, Gloyn AL, Johnson JD, Pepper AR, Lynn FC, Xia J, MacDonald PE. bioRxiv. 2024 Jun 22:2024.06.19.599613. doi: 10.1101/2024.06.19.599613. PMID:38948734…
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